Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Sodium/calcium exchanger protein | 0.007 | 0.2715 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.01 | 0.4729 | 0.3062 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0066 | 0.2403 | 0.2075 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0066 | 0.2403 | 0.2075 |
Echinococcus multilocularis | sodium calcium exchanger | 0.0176 | 1 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0066 | 0.2403 | 0.2075 |
Echinococcus granulosus | transient receptor potential ion channel A | 0.0096 | 0.45 | 0.4262 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0414 | 0.0233 |
Echinococcus granulosus | transient receptor potential gamma protein | 0.01 | 0.4729 | 0.4501 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0096 | 0.45 | 0.4262 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2715 | 0.2578 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.01 | 0.4729 | 0.4501 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.01 | 0.4729 | 0.3062 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.2174 | 0.2026 |
Loa Loa (eye worm) | solute carrier family 8 | 0.0176 | 1 | 1 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0066 | 0.2403 | 0.2075 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.4729 | 0.463 |
Schistosoma mansoni | sodium/calcium exchanger | 0.0176 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.