Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | prolyl endopeptidase | 0.0179 | 0.3016 | 0.1724 |
Trypanosoma brucei | prolyl endopeptidase | 0.0179 | 0.3016 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0179 | 0.3016 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0179 | 0.3016 | 0.1724 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0138 | 0.1561 | 0.1561 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0378 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0179 | 0.3016 | 0.1724 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0378 | 1 | 1 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0179 | 0.3016 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0179 | 0.3016 | 0.3016 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0378 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0378 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.3016 | 0.3016 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0378 | 1 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0135 | 0.1455 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0179 | 0.3016 | 0.1724 |
Toxoplasma gondii | prolyl endopeptidase | 0.0179 | 0.3016 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.