Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0262 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0262 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0262 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1788 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0262 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0262 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0262 | 0 | 0.5 |
Toxoplasma gondii | AGC kinase | 0.0262 | 0 | 0.5 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.1533 | 0.8333 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0818 | 0.3647 | 0.3647 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.1788 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0262 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0262 | 0 | 0.5 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.0818 | 0.3647 | 0.3647 |
Trichomonas vaginalis | AGC family protein kinase | 0.0262 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0262 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0262 | 0 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0262 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0262 | 0 | 0.5 |
Brugia malayi | map kinase activated protein kinase protein 2 | 0.0818 | 0.3647 | 0.4377 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.0818 | 0.3647 | 0.3647 |
Trichomonas vaginalis | AGC family protein kinase | 0.0262 | 0 | 0.5 |
Brugia malayi | ribosomal protein S6 kinase alpha 3 | 0.1533 | 0.8333 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0262 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0262 | 0 | 0.5 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.0818 | 0.3647 | 0.3647 |
Giardia lamblia | Kinase, AGC AKT | 0.1533 | 0.8333 | 0.5 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.1788 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 2 % | Compound was evaluated for inhibition of phospholipase A2 (PLA2) isolated from human platelets at a concentration of 10 microM | ChEMBL. | No reference |
Inhibition (binding) | = 2 % | Compound was evaluated for inhibition of phospholipase A2 (PLA2) isolated from human platelets at a concentration of 10 microM | ChEMBL. | No reference |
Inhibition (binding) | = 23 % | Compound was evaluated for inhibition of phospholipase A2 (PLA2) isolated from human platelets at a concentration of 100 microM. | ChEMBL. | No reference |
Inhibition (binding) | = 23 % | Compound was evaluated for inhibition of phospholipase A2 (PLA2) isolated from human platelets at a concentration of 100 microM. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.