Detailed information for compound 1479317

Basic information

Technical information
  • TDR Targets ID: 1479317
  • Name: 1-azabicyclo[2.2.2]octan-8-yl 3-hydroxy-2,2-d i(phenyl)propanoate
  • MW: 351.439 | Formula: C22H25NO3
  • H donors: 1 H acceptors: 2 LogP: 3.17 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(c1ccccc1)(c1ccccc1)C(=O)OC1CN2CCC1CC2
  • InChi: 1S/C22H25NO3/c24-16-22(18-7-3-1-4-8-18,19-9-5-2-6-10-19)21(25)26-20-15-23-13-11-17(20)12-14-23/h1-10,17,20,24H,11-16H2
  • InChiKey: VHKOZTIPJRRUQY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • quinuclidin-3-yl 3-hydroxy-2,2-di(phenyl)propanoate
  • 3-hydroxy-2,2-di(phenyl)propanoic acid 3-quinuclidinyl ester
  • 3-hydroxy-2,2-di(phenyl)propionic acid quinuclidin-3-yl ester
  • TimTec1_007160
  • Oprea1_793460
  • BAS 03439409

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.007 0.1436 0.1436
Brugia malayi STAT protein, DNA binding domain containing protein 0.0094 0.3615 0.3615
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0164 1 1
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Echinococcus granulosus SH2 domain containing adapter protein F 0.0094 0.3615 0.2544
Loa Loa (eye worm) TK/KIN16 protein kinase 0.007 0.1436 0.1436
Loa Loa (eye worm) RGC/RGC protein kinase 0.007 0.1436 0.1436
Trichomonas vaginalis protein tyrosine kinase, putative 0.007 0.1436 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Loa Loa (eye worm) TK/FER protein kinase 0.0164 1 1
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Echinococcus granulosus tyrosine protein kinase Fyn 0.0164 1 1
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Loa Loa (eye worm) serine/threonine protein kinase 0.007 0.1436 0.1436
Loa Loa (eye worm) TK protein kinase 0.007 0.1436 0.1436
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Onchocerca volvulus 0.0164 1 1
Brugia malayi tRNA modification GTPase TrmE family protein 0.0094 0.3615 0.3615
Loa Loa (eye worm) TK/ALK protein kinase 0.007 0.1436 0.1436
Toxoplasma gondii STE kinase 0.007 0.1436 0.5
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0094 0.3615 0.2544
Loa Loa (eye worm) TK protein kinase 0.007 0.1436 0.1436
Trichomonas vaginalis TK family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis conserved hypothetical protein 0.007 0.1436 0.5
Loa Loa (eye worm) TK protein kinase 0.007 0.1436 0.1436
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0164 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0164 1 1
Plasmodium falciparum protein kinase, putative 0.007 0.1436 0.5
Loa Loa (eye worm) TK/ROR protein kinase 0.007 0.1436 0.1436
Echinococcus multilocularis N chimaerin 0.0094 0.3615 0.2544
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0094 0.3615 0.2544
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Brugia malayi SH2 domain containing protein 0.0164 1 1
Loa Loa (eye worm) TK/FAK protein kinase 0.007 0.1436 0.1436
Echinococcus granulosus tyrosine protein kinase Src42A 0.0094 0.3615 0.2544
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0094 0.3615 0.2544
Brugia malayi hypothetical protein 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0164 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.1436 0.1436
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.007 0.1436 0.1436
Brugia malayi SRC-1 0.0164 1 1
Loa Loa (eye worm) TK protein kinase 0.0164 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0094 0.3615 0.2544
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0164 1 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Echinococcus granulosus tyrosine protein kinase Srms 0.0164 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0094 0.3615 0.2544
Echinococcus granulosus SHC transforming protein 3 0.0094 0.3615 0.2544
Echinococcus granulosus SH2 motif 0.0094 0.3615 0.2544
Trichomonas vaginalis conserved hypothetical protein 0.007 0.1436 0.5
Schistosoma mansoni tyrosine kinase 0.0164 1 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0094 0.3615 0.2544
Echinococcus granulosus N chimaerin 0.0094 0.3615 0.2544
Loa Loa (eye worm) TK protein kinase 0.007 0.1436 0.1436
Brugia malayi bone morphogenetic protein type 1 receptor 0.007 0.1436 0.1436
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0164 1 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.007 0.1436 0.1436
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.1436 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0164 1 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0094 0.3615 0.2544
Loa Loa (eye worm) TK/CSK protein kinase 0.007 0.1436 0.1436
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trypanosoma brucei Pseudokinase, putative 0.007 0.1436 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0164 1 1
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Trichomonas vaginalis serine-threonine protein kinase, putative 0.007 0.1436 0.5
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0094 0.3615 0.2544
Loa Loa (eye worm) hypothetical protein 0.0164 1 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0094 0.3615 0.2544
Onchocerca volvulus 0.0164 1 1
Schistosoma mansoni tensin 0.0094 0.3615 0.2544
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.1436 0.1436
Brugia malayi RhoGAP domain containing protein 0.0094 0.3615 0.3615
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0094 0.3615 0.2544
Echinococcus multilocularis SH2 motif 0.0094 0.3615 0.2544
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Echinococcus granulosus tyrosine kinase 0.0164 1 1
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.007 0.1436 0.1436
Brugia malayi protein-tyrosine kinase 0.0164 1 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) TK protein kinase 0.007 0.1436 0.1436
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Onchocerca volvulus 0.0094 0.3615 0.2544
Brugia malayi Immunoglobulin I-set domain containing protein 0.007 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0094 0.3615 0.2544
Brugia malayi Immunoglobulin I-set domain containing protein 0.007 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Onchocerca volvulus 0.0094 0.3615 0.2544
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0164 1 1
Onchocerca volvulus 0.0164 1 1
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.007 0.1436 0.1436
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.007 0.1436 0.5
Giardia lamblia Kinase, NEK 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Echinococcus granulosus SH2 motif 0.0094 0.3615 0.2544
Schistosoma mansoni nck2/grb4 0.0094 0.3615 0.2544
Trypanosoma cruzi protein kinase, putative 0.007 0.1436 0.5
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0164 1 1
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0094 0.3615 0.3615
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0094 0.3615 0.3615
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) TK/ACK protein kinase 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) TK protein kinase 0.007 0.1436 0.1436
Brugia malayi SH2 domain containing protein 0.0094 0.3615 0.3615
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Echinococcus granulosus signal transduction protein lnk realted 0.0094 0.3615 0.2544
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Onchocerca volvulus 0.0094 0.3615 0.2544
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0164 1 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.1436 0.5
Brugia malayi hypothetical protein 0.0164 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Brugia malayi Protein kinase domain containing protein 0.0164 1 1
Echinococcus multilocularis SHC transforming protein 3 0.0094 0.3615 0.2544
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0094 0.3615 0.2544
Echinococcus granulosus tyrosine protein kinase Blk 0.0164 1 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0094 0.3615 0.2544
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0094 0.3615 0.2544
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Echinococcus multilocularis tyrosine protein kinase Abl 0.0164 1 1
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0094 0.3615 0.2544
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.007 0.1436 0.5
Loa Loa (eye worm) protein kinase domain-containing protein 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Brugia malayi Probable tyrosine-protein kinase kin-31 0.007 0.1436 0.1436
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Onchocerca volvulus 0.0094 0.3615 0.2544
Echinococcus granulosus tensin 0.0094 0.3615 0.2544
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0094 0.3615 0.2544
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) SRC-1 0.0164 1 1
Echinococcus multilocularis NCK adaptor protein 0.0094 0.3615 0.2544
Brugia malayi hypothetical protein 0.0094 0.3615 0.3615
Schistosoma mansoni tyrosine kinase 0.0164 1 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.007 0.1436 0.1436
Loa Loa (eye worm) TK/FER protein kinase 0.0164 1 1
Brugia malayi SH2 domain containing protein 0.0094 0.3615 0.3615
Trichomonas vaginalis AGC family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Schistosoma mansoni shc transforming protein 0.0094 0.3615 0.2544
Echinococcus multilocularis tyrosine protein kinase Blk 0.0164 1 1
Plasmodium falciparum protein kinase, putative 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0094 0.3615 0.2544
Brugia malayi SH2 domain containing protein 0.0094 0.3615 0.3615
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Brugia malayi Protein kinase domain containing protein 0.0164 1 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Brugia malayi Variant SH3 domain containing protein 0.0094 0.3615 0.3615
Schistosoma mansoni hypothetical protein 0.0094 0.3615 0.2544
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.1436 0.1436
Schistosoma mansoni tyrosine kinase 0.0164 1 1
Echinococcus multilocularis 0.0094 0.3615 0.2544
Loa Loa (eye worm) TK/KIN6 protein kinase 0.007 0.1436 0.1436
Schistosoma mansoni tensin 0.0094 0.3615 0.2544
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) TK/Met protein kinase 0.007 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0164 1 1
Plasmodium falciparum tyrosine kinase-like protein 0.007 0.1436 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.0094 0.3615 0.2544
Onchocerca volvulus 0.0094 0.3615 0.2544
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Brugia malayi SH2 domain containing protein 0.0094 0.3615 0.3615
Brugia malayi Furin-like cysteine rich region family protein 0.007 0.1436 0.1436
Loa Loa (eye worm) TK protein kinase 0.007 0.1436 0.1436
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0164 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0164 1 1
Entamoeba histolytica SH2 domain containing protein 0.0094 0.3615 0.2544
Echinococcus granulosus suppressor of cytokine signaling 7 0.0094 0.3615 0.2544
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Echinococcus multilocularis SH2 motif 0.0094 0.3615 0.2544
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.007 0.1436 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0164 1 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0164 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0164 1 1
Echinococcus granulosus SH2 domain containing protein 7 0.0094 0.3615 0.2544
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Schistosoma mansoni hypothetical protein 0.0094 0.3615 0.2544
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0094 0.3615 0.2544
Echinococcus multilocularis tyrosine protein kinase shark 0.0164 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Loa Loa (eye worm) TK/RYK protein kinase 0.007 0.1436 0.1436
Loa Loa (eye worm) TK/FER protein kinase 0.0164 1 1
Schistosoma mansoni suppressor of cytokine signaling 0.0094 0.3615 0.2544
Trypanosoma cruzi protein kinase, putative 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Brugia malayi integrin-linked kinase 0.007 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0094 0.3615 0.2544
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0164 1 1
Schistosoma mansoni tyrosine kinase 0.0164 1 1
Echinococcus granulosus hypothetical protein 0.0094 0.3615 0.2544
Schistosoma mansoni tensin-related 0.0094 0.3615 0.2544
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0094 0.3615 0.2544
Brugia malayi Tensin 0.0094 0.3615 0.3615
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0164 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.007 0.1436 0.5
Echinococcus granulosus suppressor of cytokine signaling 6 0.0094 0.3615 0.2544
Schistosoma mansoni tensin-related 0.0094 0.3615 0.2544
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Trypanosoma brucei Flagellum attachment zone protein 20 0.007 0.1436 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Brugia malayi Sex muscle abnormal protein 5 0.0094 0.3615 0.3615
Loa Loa (eye worm) RGC/RGC protein kinase 0.007 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Toxoplasma gondii protein kinase domain-containing protein 0.007 0.1436 0.5
Brugia malayi C-terminal src kinase protein 1 0.007 0.1436 0.1436
Loa Loa (eye worm) RGC/RGC protein kinase 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.0094 0.3615 0.3615
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Echinococcus granulosus growth factor receptor bound protein 2 0.0094 0.3615 0.2544
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0094 0.3615 0.2544
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0164 1 1
Giardia lamblia Kinase 0.007 0.1436 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Loa Loa (eye worm) TK/INSR protein kinase 0.007 0.1436 0.1436
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0164 1 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.007 0.1436 0.1436
Trichomonas vaginalis protein kinase atn1, putative 0.007 0.1436 0.5
Brugia malayi Protein kinase domain containing protein 0.0164 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Schistosoma mansoni tensin 0.0094 0.3615 0.2544
Echinococcus multilocularis SH2 motif 0.0094 0.3615 0.2544
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0164 1 1
Schistosoma mansoni tyrosine kinase 0.0164 1 1
Trichomonas vaginalis CAMK family protein kinase 0.007 0.1436 0.5
Onchocerca volvulus 0.0164 1 1
Leishmania major protein kinase, putative 0.007 0.1436 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.0164 1 1
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Loa Loa (eye worm) TK/FER protein kinase 0.0164 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0164 1 1
Toxoplasma gondii protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0094 0.3615 0.3615
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.007 0.1436 0.5
Schistosoma mansoni vav2 0.0094 0.3615 0.2544
Loa Loa (eye worm) TK protein kinase 0.007 0.1436 0.1436
Trichomonas vaginalis conserved hypothetical protein 0.007 0.1436 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0164 1 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Schistosoma mansoni adapter molecule crk 0.0094 0.3615 0.2544
Giardia lamblia Kinase, NEK 0.007 0.1436 0.5
Brugia malayi hypothetical protein 0.007 0.1436 0.1436
Brugia malayi Guanylyl cyclase protein 23 0.007 0.1436 0.1436
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0094 0.3615 0.3615
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Brugia malayi Variant SH3 domain containing protein 0.0094 0.3615 0.3615
Schistosoma mansoni growth factor receptor-bound protein 0.0094 0.3615 0.2544
Echinococcus multilocularis tensin 0.0094 0.3615 0.2544
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0164 1 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Echinococcus granulosus tyrosine protein kinase Lyn 0.0164 1 1
Brugia malayi Variant SH3 domain containing protein 0.0094 0.3615 0.3615
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.007 0.1436 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0094 0.3615 0.2544
Loa Loa (eye worm) SH2 domain-containing protein 0.0094 0.3615 0.3615
Leishmania major protein kinase, putative 0.007 0.1436 0.5
Trichomonas vaginalis conserved hypothetical protein 0.007 0.1436 0.5
Plasmodium vivax protein kinase, putative 0.007 0.1436 0.5
Schistosoma mansoni signal transduction protein lnk-related 0.0094 0.3615 0.2544
Brugia malayi Tyrosine-protein kinase PR2 0.007 0.1436 0.1436
Onchocerca volvulus 0.0164 1 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0094 0.3615 0.2544
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Onchocerca volvulus 0.0164 1 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Schistosoma mansoni GTPase activating protein 0.0094 0.3615 0.2544
Schistosoma mansoni SH2A 0.0094 0.3615 0.2544
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Brugia malayi SH2 domain containing protein 0.0094 0.3615 0.3615
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0094 0.3615 0.3615
Echinococcus multilocularis signal transduction protein lnk realted 0.0094 0.3615 0.2544
Loa Loa (eye worm) TK/FER protein kinase 0.0164 1 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0094 0.3615 0.3615
Loa Loa (eye worm) TK/FER protein kinase 0.0164 1 1
Echinococcus multilocularis tyrosine kinase 0.0164 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0164 1 1
Echinococcus granulosus expressed conserved protein 0.0094 0.3615 0.2544
Loa Loa (eye worm) TK/EPH protein kinase 0.007 0.1436 0.1436
Echinococcus granulosus tyrosine protein kinase shark 0.0164 1 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.0164 1 1
Plasmodium falciparum protein kinase, putative 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Leishmania major hypothetical protein, conserved 0.007 0.1436 0.5
Echinococcus granulosus NCK adaptor protein 0.0094 0.3615 0.2544
Brugia malayi ephrin receptor 1 precursor 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Echinococcus multilocularis SH2 domain containing protein 7 0.0094 0.3615 0.2544
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Onchocerca volvulus 0.0094 0.3615 0.2544
Echinococcus granulosus c src tyrosine kinase 0.0164 1 1
Trypanosoma brucei protein kinase, putative 0.007 0.1436 0.5
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Echinococcus multilocularis c src tyrosine kinase 0.0164 1 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.007 0.1436 0.5
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.007 0.1436 0.1436
Trichomonas vaginalis STE family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Brugia malayi Raf kinase 0.007 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Plasmodium vivax tyrosine kinase-like protein, putative 0.007 0.1436 0.5
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0164 1 1
Brugia malayi Protein kinase domain containing protein 0.0164 1 1
Brugia malayi SH2 domain containing protein 0.0094 0.3615 0.3615
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0164 1 1
Brugia malayi Receptor family ligand binding region containing protein 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.0094 0.3615 0.3615
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Brugia malayi SH2 domain containing protein 0.0094 0.3615 0.3615
Brugia malayi cytokine inducible SH2-containing protein 5 0.0094 0.3615 0.3615
Loa Loa (eye worm) hypothetical protein 0.007 0.1436 0.1436
Schistosoma mansoni tyrosine kinase 0.0164 1 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.007 0.1436 0.5
Loa Loa (eye worm) STAT protein 0.0094 0.3615 0.3615
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Echinococcus granulosus tyrosine kinase 0.0164 1 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Entamoeba histolytica protein kinase, putative 0.0094 0.3615 0.2544
Brugia malayi SH2 domain containing protein 0.0164 1 1
Loa Loa (eye worm) TK/DDR protein kinase 0.007 0.1436 0.1436
Echinococcus granulosus tyrosine protein kinase Src64B 0.0164 1 1
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Trichomonas vaginalis conserved hypothetical protein 0.007 0.1436 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0094 0.3615 0.2544
Giardia lamblia Protein 21.1 0.007 0.1436 0.5
Brugia malayi Protein kinase domain containing protein 0.007 0.1436 0.1436
Brugia malayi Probable tyrosine-protein kinase kin-31 0.007 0.1436 0.1436
Echinococcus multilocularis tensin 0.0094 0.3615 0.2544
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.007 0.1436 0.1436
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) hypothetical protein 0.0094 0.3615 0.3615
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0094 0.3615 0.3615
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Trichomonas vaginalis TKL family protein kinase 0.007 0.1436 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.007 0.1436 0.1436
Plasmodium falciparum tyrosine kinase-like protein 0.007 0.1436 0.5
Brugia malayi Tyrosine-protein kinase abl-1 0.0164 1 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.1436 0.5
Brugia malayi Variant SH3 domain containing protein 0.0094 0.3615 0.3615
Loa Loa (eye worm) TK protein kinase 0.007 0.1436 0.1436

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.