Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | peptide deformylase, putative | 0.0549 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.5076 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0369 | 0.5005 | 1 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0371 | 0.5076 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0369 | 0.5005 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0361 | 0.4794 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0549 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0369 | 0.5005 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 0.5005 | 0.986 |
Mycobacterium ulcerans | peptide deformylase | 0.0549 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0549 | 1 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0549 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0549 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0549 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0549 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.