Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | carbonic anhydrase, putative | 0.0233 | 0.7153 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0101 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0249 | 0.8027 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0249 | 0.8027 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0249 | 0.8027 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0249 | 0.8027 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0249 | 0.8027 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 1 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0233 | 0.7153 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0132 | 0.1703 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0233 | 0.7153 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0249 | 0.8027 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0101 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.