Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0052 | 1 | 0.5 | |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0052 | 1 | 0.5 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0052 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0052 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 1 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0052 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0052 | 1 | 0.5 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0052 | 1 | 0.5 |
Onchocerca volvulus | Deterin homolog | 0.0052 | 1 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0052 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0026 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.