Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D3 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | dopamine receptor D3 | 400 aa | 392 aa | 19.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0668 | 0.4182 | 0.3671 |
Onchocerca volvulus | 0.078 | 0.5352 | 0.4944 | |
Brugia malayi | Trypsin family protein | 0.1126 | 0.8969 | 0.8878 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1126 | 0.8969 | 0.8878 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.1224 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.1224 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0346 | 0.0807 | 0.5 |
Brugia malayi | Muscle positioning protein 4 | 0.0744 | 0.4975 | 0.4534 |
Loa Loa (eye worm) | hypothetical protein | 0.1126 | 0.8969 | 0.8878 |
Onchocerca volvulus | 0.0668 | 0.4182 | 0.3671 | |
Brugia malayi | Kringle domain containing protein | 0.1224 | 1 | 1 |
Loa Loa (eye worm) | DOMON domain-containing protein | 0.0668 | 0.4182 | 0.3671 |
Onchocerca volvulus | 0.0744 | 0.4975 | 0.4534 | |
Schistosoma mansoni | hypothetical protein | 0.0668 | 0.4182 | 0.3671 |
Leishmania major | hypothetical protein, conserved | 0.1224 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0353 | 0.0882 | 0.0081 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.1224 | 1 | 0.5 |
Onchocerca volvulus | 0.1224 | 1 | 1 | |
Onchocerca volvulus | 0.0668 | 0.4182 | 0.3671 | |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.1224 | 1 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.1224 | 1 | 1 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.1224 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1126 | 0.8969 | 0.8878 |
Loa Loa (eye worm) | hypothetical protein | 0.1224 | 1 | 1 |
Brugia malayi | SEA domain containing protein | 0.0668 | 0.4182 | 0.3671 |
Onchocerca volvulus | 0.0668 | 0.4182 | 0.3671 | |
Toxoplasma gondii | kringle domain-containing protein | 0.1224 | 1 | 1 |
Onchocerca volvulus | 0.0668 | 0.4182 | 0.3671 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.1148 | 0.9208 | 0.9138 |
Onchocerca volvulus | 0.1126 | 0.8969 | 0.8878 | |
Loa Loa (eye worm) | hypothetical protein | 0.0744 | 0.4975 | 0.4534 |
Schistosoma mansoni | hypothetical protein | 0.1224 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS of D3 Dopamine Receptor Agonist: D3 Dopamine Receptor B-arrestin Agonist Confirmatory Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.