Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.097 | 0.2442 | 1 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.097 | 0.2442 | 0.5 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.097 | 0.2442 | 0.2442 |
Schistosoma mansoni | sodium/solute symporter | 0.097 | 0.2442 | 0.2442 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.097 | 0.2442 | 0.2442 |
Schistosoma mansoni | inositol transporter | 0.3803 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0013 | 0.0054 |
Echinococcus granulosus | solute carrier family 5 | 0.3803 | 1 | 1 |
Schistosoma mansoni | inositol transporter | 0.3803 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0013 | 0.0054 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.097 | 0.2442 | 0.2442 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.3803 | 1 | 1 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.3803 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.097 | 0.2442 | 1 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.097 | 0.2442 | 0.2442 |
Echinococcus multilocularis | solute carrier family 5 | 0.3803 | 1 | 1 |
Brugia malayi | Sodium:solute symporter family protein | 0.097 | 0.2442 | 1 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.3803 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0013 | 0.0054 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.3803 | 1 | 1 |
Brugia malayi | GH02984p | 0.097 | 0.2442 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0013 | 0.0054 |
Schistosoma mansoni | high-affinity choline transporter | 0.097 | 0.2442 | 0.2442 |
Onchocerca volvulus | 0.097 | 0.2442 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 29.9349 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.