Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hexokinase | 0.0154 | 0.0367 | 0.0367 |
Loa Loa (eye worm) | hypothetical protein | 0.0853 | 0.5641 | 0.5501 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0853 | 0.5641 | 0.5641 |
Brugia malayi | hexokinase | 0.0154 | 0.0367 | 0.0367 |
Toxoplasma gondii | V-type H(+)-translocating pyrophosphatase VP1 | 0.0495 | 0.2944 | 0.4887 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0853 | 0.5641 | 0.5641 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 1 | 0.0495 | 0.2944 | 0.2676 |
Loa Loa (eye worm) | matrixin family protein | 0.0165 | 0.0448 | 0.0142 |
Brugia malayi | Matrixin family protein | 0.0252 | 0.1105 | 0.1105 |
Treponema pallidum | hexokinase (hxk) | 0.0154 | 0.0367 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1431 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0154 | 0.0367 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0853 | 0.5641 | 0.5501 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1431 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0853 | 0.5641 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1431 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0853 | 0.5641 | 0.5475 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0342 | 0.1788 | 0.1476 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0853 | 0.5641 | 0.5501 |
Loa Loa (eye worm) | hexokinase type II | 0.0154 | 0.0367 | 0.0058 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0853 | 0.5641 | 0.5641 |
Echinococcus granulosus | carbonic anhydrase | 0.0853 | 0.5641 | 0.5475 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1431 | 1 | 1 |
Plasmodium falciparum | V-type H(+)-translocating pyrophosphatase, putative | 0.0495 | 0.2944 | 0.4887 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0495 | 0.2944 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0154 | 0.0367 | 0.0058 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0165 | 0.0448 | 0.4515 |
Entamoeba histolytica | hexokinase 1 | 0.0154 | 0.0367 | 0.5 |
Leishmania major | carbonic anhydrase-like protein | 0.1431 | 1 | 1 |
Plasmodium falciparum | V-type K+-independent H+-translocating inorganic pyrophosphatase | 0.0495 | 0.2944 | 0.4887 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0146 | 0.0311 | 0.0311 |
Echinococcus multilocularis | carbonic anhydrase | 0.0853 | 0.5641 | 0.5475 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1431 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0853 | 0.5641 | 0.5641 |
Onchocerca volvulus | 0.0154 | 0.0367 | 0.3691 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0853 | 0.5641 | 0.5641 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0853 | 0.5641 | 0.5641 |
Onchocerca volvulus | 0.0154 | 0.0367 | 0.3691 | |
Onchocerca volvulus | Matrilysin homolog | 0.0237 | 0.0993 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0853 | 0.5641 | 0.5641 |
Leishmania major | vacuolar-type proton translocating pyrophosphatase 1, putative | 0.0495 | 0.2944 | 0.2676 |
Entamoeba histolytica | hexokinase 2 | 0.0154 | 0.0367 | 0.5 |
Onchocerca volvulus | 0.0154 | 0.0367 | 0.3691 | |
Loa Loa (eye worm) | matrixin family protein | 0.0252 | 0.1105 | 0.082 |
Loa Loa (eye worm) | hypothetical protein | 0.0853 | 0.5641 | 0.5501 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0853 | 0.5641 | 0.5641 |
Trypanosoma cruzi | vacuolar-type proton translocating pyrophosphatase 1 | 0.0495 | 0.2944 | 0.2676 |
Echinococcus granulosus | carbonic anhydrase II | 0.1431 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0853 | 0.5641 | 0.5475 |
Toxoplasma gondii | hypothetical protein | 0.0853 | 0.5641 | 1 |
Brugia malayi | Hexokinase family protein | 0.0154 | 0.0367 | 0.0367 |
Schistosoma mansoni | carbonic anhydrase | 0.0853 | 0.5641 | 0.5641 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1431 | 1 | 1 |
Trypanosoma brucei | Pyrophosphate-energized vacuolar membrane proton pump 2, putative | 0.0495 | 0.2944 | 0.2676 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1431 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0342 | 0.1788 | 0.1476 |
Echinococcus granulosus | carbonic anhydrase | 0.0853 | 0.5641 | 0.5475 |
Schistosoma mansoni | hypothetical protein | 0.0853 | 0.5641 | 0.5641 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0495 | 0.2944 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1431 | 1 | 1 |
Trypanosoma cruzi | Vacuolar proton pyrophosphatase 1, putative | 0.0495 | 0.2944 | 0.2676 |
Echinococcus multilocularis | carbonic anhydrase | 0.0853 | 0.5641 | 0.5475 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1431 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.