Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0572 | 0.5231 | 0.5341 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 0.5231 | 0.5341 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0572 | 0.5231 | 0.5354 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0572 | 0.5231 | 0.5341 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.096 | 0.9771 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0925 | 0.0156 |
Plasmodium falciparum | carbonic anhydrase | 0.0572 | 0.5231 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0572 | 0.5231 | 0.5354 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0572 | 0.5231 | 0.5341 |
Schistosoma mansoni | hypothetical protein | 0.0572 | 0.5231 | 0.5354 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.096 | 0.9771 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 0.5231 | 0.5341 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.096 | 0.9771 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.096 | 0.9771 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0572 | 0.5231 | 0.5341 |
Echinococcus multilocularis | carbonic anhydrase | 0.0572 | 0.5231 | 0.4827 |
Echinococcus granulosus | carbonic anhydrase | 0.0572 | 0.5231 | 0.495 |
Toxoplasma gondii | hypothetical protein | 0.0572 | 0.5231 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.096 | 0.9771 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0572 | 0.5231 | 0.5341 |
Plasmodium vivax | V-type H(+)-translocating pyrophosphatase, putative | 0.0363 | 0.2783 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0925 | 0.0947 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.096 | 0.9771 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0572 | 0.5231 | 0.495 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.096 | 0.9771 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0572 | 0.5231 | 0.5341 |
Echinococcus granulosus | carbonic anhydrase | 0.0572 | 0.5231 | 0.495 |
Echinococcus granulosus | carbonic anhydrase II | 0.096 | 0.9771 | 1 |
Plasmodium vivax | vacuolar-type H+ pumping pyrophosphatase, putative | 0.0363 | 0.2783 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.096 | 0.9771 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0572 | 0.5231 | 0.5341 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0925 | 0.0947 |
Echinococcus multilocularis | carbonic anhydrase II | 0.096 | 0.9771 | 0.9752 |
Echinococcus granulosus | geminin | 0.0205 | 0.0925 | 0.016 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0572 | 0.5231 | 0.5354 |
Echinococcus multilocularis | carbonic anhydrase | 0.0572 | 0.5231 | 0.4827 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.096 | 0.9771 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0572 | 0.5231 | 0.5354 |
Echinococcus multilocularis | carbonic anhydrase | 0.0572 | 0.5231 | 0.4827 |
Leishmania major | carbonic anhydrase-like protein | 0.096 | 0.9771 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0065 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.7305 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.