Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, muscarinic 1 | Starlite/ChEMBL | References |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glycogen phosphorylase | 0.0224 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.8679 | 0.8679 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0224 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0224 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0224 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0224 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0224 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0224 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0224 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0224 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0097 | 0.1501 | 0.1501 |
Schistosoma mansoni | glycogen phosphorylase | 0.0224 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0224 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0224 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0224 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0205 | 0.8679 | 0.8679 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0097 | 0.1501 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.0224 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0224 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0224 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8679 | 0.8679 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0097 | 0.1501 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.8679 | 0.8679 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | Antagonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by fluorescence assay | ChEMBL. | 22197142 |
Potency (functional) | 0.3264 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.