Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0313 | 0.2266 | 0.2266 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0696 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0373 | 0.3466 | 0.1837 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0342 | 0.2844 | 0.2844 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0696 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.044 | 0.4815 | 0.4815 |
Echinococcus granulosus | glutamate receptor 2 | 0.0458 | 0.5185 | 0.5185 |
Echinococcus granulosus | glutamate receptor 2 | 0.0342 | 0.2844 | 0.2844 |
Echinococcus multilocularis | NMDA receptor | 0.044 | 0.4815 | 0.4815 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0398 | 0.3985 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0696 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0398 | 0.3985 | 0.3985 |
Schistosoma mansoni | glutamate receptor kainate | 0.0637 | 0.88 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0313 | 0.2266 | 0.2266 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0398 | 0.3985 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.044 | 0.4815 | 0.4815 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.044 | 0.4815 | 0.4815 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0458 | 0.5185 | 0.5185 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0458 | 0.5185 | 0.5185 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.044 | 0.4815 | 0.4815 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0696 | 1 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0398 | 0.3985 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0458 | 0.5185 | 0.5185 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0696 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0637 | 0.88 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.