Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | No references |
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5 | 0.5 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0105 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5 | 0.5 |
Onchocerca volvulus | Deterin homolog | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0105 | 0.5 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0105 | 0.5 | 0.5 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0105 | 0.5 | 0.5 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0105 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0105 | 0.5 | 0.5 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0105 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0105 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 24.1 uM | PUBCHEM_BIOASSAY: SAR analysis of agonists of the Cannabinoid Receptor 2 using an Image-Based Assay - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
EC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of agonists of the Cannabinoid Receptor 1 using an Image-Based Assay - Set 4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
EC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of Agonists of the GPR35 Receptor using an Image-Based Assay - Set 4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
IC50 (functional) | = 1.68 uM | PUBCHEM_BIOASSAY: SAR analysis of antagonists of the Cannabinoid Receptor 1 using an Image-Based Assay - Set 4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
IC50 (functional) | > 9.18 uM | PUBCHEM_BIOASSAY: SAR analysis of antagonists of the Cannabinoid Receptor 2 using an Image-Based Assay - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
IC50 (functional) | = 21.5 uM | PUBCHEM_BIOASSAY: SAR Analysis of Selective Antagonists of GPR55 using an Image-Based Assay - Set 4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
IC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of the GPR35 Receptor using an Image-Based Assay - Set 6. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2013, AID2026] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.