Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0129 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0129 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0129 | 0.0178 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0129 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.1441 | 0.7244 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0129 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0129 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0541 | 0.2665 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0541 | 0.2665 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0541 | 0.2665 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0541 | 0.2665 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0129 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0541 | 0.2665 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0541 | 0.2665 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0541 | 0.2665 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0129 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0541 | 0.2665 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0129 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.