Detailed information for compound 1485099

Basic information

Technical information
  • TDR Targets ID: 1485099
  • Name: 4-[(2S)-3-methyl-1-phenylsulfanylbutan-2-yl]- 1-(phenylmethyl)-1,4-diazepan-5-one
  • MW: 382.562 | Formula: C23H30N2OS
  • H donors: 0 H acceptors: 1 LogP: 4.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC([C@H](N1CCN(CCC1=O)Cc1ccccc1)CSc1ccccc1)C
  • InChi: 1S/C23H30N2OS/c1-19(2)22(18-27-21-11-7-4-8-12-21)25-16-15-24(14-13-23(25)26)17-20-9-5-3-6-10-20/h3-12,19,22H,13-18H2,1-2H3/t22-/m1/s1
  • InChiKey: ISQPGZBBUHCHRU-JOCHJYFZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[(1S)-2-methyl-1-(phenylsulfanylmethyl)propyl]-1-(phenylmethyl)-1,4-diazepan-5-one
  • 4-[(1S)-2-methyl-1-[(phenylthio)methyl]propyl]-1-(phenylmethyl)-1,4-diazepan-5-one
  • 1-(benzyl)-4-[(1S)-2-methyl-1-[(phenylthio)methyl]propyl]-1,4-diazepan-5-one
  • 4-[(2S)-3-methyl-1-phenylsulfanyl-butan-2-yl]-1-(phenylmethyl)-1,4-diazepan-5-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis G protein coupled receptor 139 0.0041 0.024 0.0312
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Trichomonas vaginalis ap endonuclease, putative 0.0011 0 0.5
Giardia lamblia Telomerase catalytic subunit 0.0346 0.2667 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0041 0.024 0.0312
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0041 0.024 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.024 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Brugia malayi hypothetical protein 0.0041 0.024 0.0332
Echinococcus granulosus neuropeptide receptor 0.0041 0.024 1
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.024 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.024 1
Schistosoma mansoni hypothetical protein 0.0041 0.024 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0041 0.024 0.0312
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0011 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.024 0.0312
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0041 0.024 1
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.024 1
Brugia malayi Serotonin receptor 0.0041 0.024 0.0332
Brugia malayi sulfakinin receptor protein 0.0041 0.024 0.0332
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus granulosus neuropeptide Y receptor 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus multilocularis g protein coupled receptor 0.0041 0.024 0.0312
Brugia malayi Melatonin receptor type 1A 0.0041 0.024 0.0332
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0041 0.024 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Brugia malayi hypothetical protein 0.0041 0.024 0.0332
Brugia malayi G-protein coupled receptor 0.0041 0.024 0.0332
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.024 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0346 0.2667 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0041 0.024 0.0332
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.024 1
Schistosoma mansoni opsin-like receptor 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0041 0.024 1
Brugia malayi G protein-coupled receptor 0.0041 0.024 0.0332
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0346 0.2667 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.024 1
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.024 0.0312
Toxoplasma gondii RNA-directed DNA polymerase 0.0346 0.2667 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0041 0.024 0.0332
Leishmania major telomerase reverse transcriptase, putative 0.0346 0.2667 1
Schistosoma mansoni biogenic amine receptor 0.0041 0.024 1
Schistosoma mansoni myosin xvIII 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Schistosoma mansoni opsin-like receptor 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0011 0 0.5
Brugia malayi AKH receptor 0.0041 0.024 0.0332
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Trichomonas vaginalis ap endonuclease, putative 0.0011 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.024 0.0312
Schistosoma mansoni neuropeptide receptor 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus granulosus allatostatin A receptor 0.0041 0.024 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0041 0.024 1
Echinococcus granulosus dro:myosuppressin receptor 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Brugia malayi ORL1-like opioid receptor 0.0041 0.024 0.0332
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.024 0.0312
Schistosoma mansoni opsin-like receptor 0.0041 0.024 1
Echinococcus granulosus g protein coupled receptor 0.0041 0.024 1
Echinococcus multilocularis neuropeptide receptor A26 0.0041 0.024 0.0312
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.024 0.0312
Schistosoma mansoni neuropeptide f receptor 76f 0.0041 0.024 1
Brugia malayi hypothetical protein 0.0041 0.024 0.0332
Trypanosoma brucei telomerase reverse transcriptase 0.0346 0.2667 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus granulosus serotonin receptor 0.0041 0.024 1
Echinococcus granulosus orexin receptor type 2 0.0041 0.024 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0041 0.024 1
Echinococcus granulosus somatostatin receptor 0.0041 0.024 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0041 0.024 1
Schistosoma mansoni amine GPCR 0.0041 0.024 1
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.024 1
Echinococcus multilocularis fmrfamide receptor 0.0041 0.024 0.0312
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0041 0.024 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0011 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.024 1
Schistosoma mansoni amine GPCR 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.024 0.0312
Echinococcus multilocularis allatostatin A receptor 0.0041 0.024 0.0312
Echinococcus multilocularis neuropeptide Y receptor 0.0041 0.024 0.0312
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0041 0.024 1
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.024 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0041 0.024 0.0312
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0041 0.024 1
Echinococcus multilocularis g protein coupled receptor 0.0041 0.024 0.0312
Echinococcus multilocularis neuropeptide receptor 0.0041 0.024 0.0312
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.024 1
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.024 1
Brugia malayi Serotonin receptor 0.0041 0.024 0.0332
Schistosoma mansoni histamine h1 receptor 0.0041 0.024 1
Brugia malayi Dopamine receptor 0.0041 0.024 0.0332
Brugia malayi Dopamine receptor protein 1 0.0041 0.024 0.0332
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0041 0.024 1
Echinococcus multilocularis neuropeptide receptor 0.0041 0.024 0.0312
Schistosoma mansoni amine GPCR 0.0041 0.024 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0041 0.024 0.0332
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0041 0.024 1
Echinococcus multilocularis serotonin receptor 0.0041 0.024 0.0312
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0041 0.024 0.0312
Brugia malayi larval opioid receptor 0.0041 0.024 0.0332
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0041 0.024 0.0332
Brugia malayi putative neuropeptide receptor 0.0041 0.024 0.0332
Echinococcus multilocularis somatostatin receptor 0.0041 0.024 0.0312
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0041 0.024 1
Schistosoma mansoni hypothetical protein 0.0041 0.024 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0041 0.024 0.0332
Brugia malayi GnHR receptor homolog 0.0041 0.024 0.0332
Brugia malayi neuropeptide F receptor 0.0041 0.024 0.0332
Echinococcus granulosus tachykinin peptides receptor 99D 0.0041 0.024 1
Loa Loa (eye worm) G-protein coupled receptor 0.0041 0.024 1
Brugia malayi hypothetical protein 0.0041 0.024 0.0332
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.024 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0041 0.024 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0041 0.024 0.0312
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.024 0.0312
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0041 0.024 1
Echinococcus granulosus g protein coupled receptor 0.0041 0.024 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.024 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.024 0.0312
Schistosoma mansoni neuropeptide receptor 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Brugia malayi hypothetical protein 0.0041 0.024 0.0332
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0041 0.024 0.0332
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus granulosus hypothetical protein 0.0041 0.024 1
Echinococcus multilocularis sex peptide receptor 0.0041 0.024 0.0312
Schistosoma mansoni biogenic amine receptor 0.0041 0.024 1
Brugia malayi hypothetical protein 0.0041 0.024 0.0332
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Brugia malayi hypothetical protein 0.0041 0.024 0.0332
Echinococcus multilocularis dro:myosuppressin receptor 0.0041 0.024 0.0312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus multilocularis g-protein coupled receptor 0.0041 0.024 0.0312
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0041 0.024 1
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.024 1
Plasmodium vivax telomerase reverse transcriptase, putative 0.0346 0.2667 1
Brugia malayi putative neuropeptide receptor NPR1 0.0041 0.024 0.0332
Schistosoma mansoni amine GPCR 0.0041 0.024 1
Plasmodium falciparum telomerase reverse transcriptase 0.0346 0.2667 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.024 1
Brugia malayi Telomerase reverse transcriptase 0.0921 0.7244 1
Loa Loa (eye worm) TYRA-2 protein 0.0041 0.024 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0041 0.024 1
Echinococcus multilocularis neuropeptides capa receptor 0.0041 0.024 0.0312
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.771 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.024 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.024 0.0312
Schistosoma mansoni neuropeptide receptor 0.0041 0.024 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.024 1
Brugia malayi hypothetical protein 0.0041 0.024 0.0332
Echinococcus multilocularis fmrfamide receptor 0.0041 0.024 0.0312
Brugia malayi G-protein coupled receptor 0.0041 0.024 0.0332
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Schistosoma mansoni adenoreceptor 0.0041 0.024 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0041 0.024 0.0312
Schistosoma mansoni neuropeptide F-like receptor 0.0041 0.024 1
Brugia malayi neuropeptide F receptor 0.0041 0.024 0.0332
Echinococcus granulosus g-protein coupled receptor 0.0041 0.024 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.024 0.0312
Echinococcus granulosus alpha 1A adrenergic receptor 0.0041 0.024 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0041 0.024 1
Brugia malayi follicle stimulating hormone receptor 0.0041 0.024 0.0332
Echinococcus granulosus neuropeptide s receptor 0.0041 0.024 1
Schistosoma mansoni neuropeptide receptor 0.0041 0.024 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.024 0.0312
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus multilocularis orexin receptor type 2 0.0041 0.024 0.0312
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Brugia malayi RE15519p 0.0041 0.024 0.0332
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0041 0.024 0.0332
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.024 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.024 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.024 0.0312
Brugia malayi hypothetical protein 0.0041 0.024 0.0332
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0011 0 0.5
Echinococcus granulosus fmrfamide receptor 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus granulosus neuropeptide receptor 0.0041 0.024 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0041 0.024 0.0312
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0041 0.024 1
Schistosoma mansoni hypothetical protein 0.0041 0.024 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.024 1
Echinococcus granulosus g protein coupled receptor 0.0041 0.024 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0041 0.024 0.0312
Schistosoma mansoni hypothetical protein 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0041 0.024 1
Echinococcus granulosus G protein coupled receptor 139 0.0041 0.024 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0041 0.024 0.0312
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0041 0.024 0.0312
Echinococcus granulosus neuropeptide receptor A26 0.0041 0.024 1
Echinococcus multilocularis g protein coupled receptor 0.0041 0.024 0.0312
Brugia malayi hypothetical protein 0.0041 0.024 0.0332
Echinococcus multilocularis neuropeptide s receptor 0.0041 0.024 0.0312
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0041 0.024 1
Schistosoma mansoni biogenic amine receptor 0.0041 0.024 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0041 0.024 1
Echinococcus granulosus sex peptide receptor 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus granulosus neuropeptides capa receptor 0.0041 0.024 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0041 0.024 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0041 0.024 0.0312
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0041 0.024 0.0312
Schistosoma mansoni amine GPCR 0.0041 0.024 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0041 0.024 0.0312
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0041 0.024 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0041 0.024 1
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.024 1
Loa Loa (eye worm) neuropeptide F receptor 0.0041 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0041 0.024 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0011 0 0.5
Echinococcus multilocularis serotonin receptor 0.0041 0.024 0.0312
Brugia malayi Dopamine receptor protein 2 0.0041 0.024 0.0332
Loa Loa (eye worm) hypothetical protein 0.0041 0.024 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0041 0.024 1
Echinococcus granulosus tm gpcr rhodopsin 0.0041 0.024 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5104 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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