Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0076 | 0.4666 | 0.4666 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4666 | 0.8686 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.008 | 0.5057 | 0.5057 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4666 | 0.4666 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4666 | 0.9226 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4666 | 0.9226 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.5057 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4666 | 0.4666 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.5371 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.008 | 0.5057 | 0.5057 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.5057 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4666 | 0.8686 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0046 | 0.0978 | 0.1933 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.5371 | 0.5371 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4666 | 0.4666 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4666 | 0.4666 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4666 | 0.8686 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4666 | 0.8686 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.008 | 0.5057 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4666 | 0.8686 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5371 | 0.5371 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.5057 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0046 | 0.0978 | 0.1933 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.008 | 0.5057 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.008 | 0.5057 | 0.9414 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4666 | 0.4666 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.008 | 0.5057 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.008 | 0.5057 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.