Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | excision repair cross-complementing 1 ercc1, putative | 0.0057 | 1 | 1 |
Plasmodium falciparum | ERCC1 nucleotide excision repair protein, putative | 0.0057 | 1 | 1 |
Brugia malayi | ERCC4 domain containing protein | 0.0041 | 0.4902 | 1 |
Trypanosoma brucei | DNA repair protein, putative | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | DNA repair protein, putative | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | DNA repair protein, putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | helix-hairpin-helix domain-containing protein family protein | 0.0057 | 1 | 1 |
Toxoplasma gondii | DNA repair protein rad10 subfamily protein | 0.0057 | 1 | 1 |
Echinococcus multilocularis | DNA excision repair protein ERCC 1 | 0.0057 | 1 | 1 |
Schistosoma mansoni | excision repair cross-complementing 1 ercc1 | 0.0057 | 1 | 1 |
Entamoeba histolytica | DNA excision repair protein, putative | 0.0057 | 1 | 1 |
Plasmodium vivax | ERCC1 nucleotide excision repair protein, putative | 0.0057 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.