Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium channel, voltage-dependent, T type, alpha 1H subunit | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | Get druggable targets OG5_129328 | All targets in OG5_129328 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | Get druggable targets OG5_129328 | All targets in OG5_129328 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129328 | All targets in OG5_129328 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA topoisomerase ii | 0.0233 | 0.872 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 0.781 | 0.781 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0259 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0233 | 0.872 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0259 | 1 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0085 | 0.1467 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0259 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2904 | 0.2904 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0259 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.5816 | 0.5816 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0259 | 1 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0247 | 0.9438 | 0.5 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0259 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0188 | 0.6504 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0259 | 1 | 0.5 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0259 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0085 | 0.1467 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.5816 | 0.5816 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2904 | 0.2904 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0259 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0233 | 0.872 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0259 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0233 | 0.872 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.014 | 0.4184 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0085 | 0.1467 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0233 | 0.872 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0188 | 0.6504 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0188 | 0.6504 | 0.5 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0085 | 0.1467 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0259 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 10 uM | PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channels (SynthLib2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID489005, AID493041, AID504579, AID504584, AID504619, AID504628] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.