Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0139 | 0.5 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0139 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0139 | 0.5 | 0.5 | |
Brugia malayi | Kringle domain containing protein | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0139 | 0.5 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0139 | 0.5 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0139 | 0.5 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0139 | 0.5 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0139 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.5 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0139 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.