Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | TYRA-2 protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Onchocerca volvulus | 0.0028 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.0028 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Inhibition of Staphylococcus aureus DNA gyrase-mediated supercoiling of relaxed DNA using pBR 322 as substrate by agarose gel electrophoresis analysis | ChEMBL. | 25288496 |
IC50 (binding) | = 77.32 uM | Inhibition of Staphylococcus aureus DNA gyrase B ATPase activity | ChEMBL. | 25288496 |
Potency (functional) | 0.8199 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 1.9953 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.