Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Brugia malayi | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Trichomonas vaginalis | mercuric reductase, putative | 0.00185989 | 0.0013659 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00427222 | 0.00823565 | 0.00823565 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00185989 | 0.0013659 | 0.5 |
Brugia malayi | glutathione reductase | 0.0053672 | 0.0113539 | 0.0113539 |
Leishmania major | ferric reductase, putative | 0.228649 | 0.647211 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0053672 | 0.0113539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.00185989 | 0.0013659 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0053672 | 0.0113539 | 0.015465 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Brugia malayi | Animal haem peroxidase family protein | 0.00427222 | 0.00823565 | 0.00823565 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.00185989 | 0.0013659 | 0.120302 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.00427222 | 0.00823565 | 0.00823565 |
Onchocerca volvulus | Peroxidase homolog | 0.00427222 | 0.00823565 | 0.00823565 |
Onchocerca volvulus | Dual oxidase homolog | 0.352532 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.00427222 | 0.00823565 | 0.00823565 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0053672 | 0.0113539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Brugia malayi | Animal haem peroxidase family protein | 0.00427222 | 0.00823565 | 0.00823565 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.00185989 | 0.0013659 | 0.5 |
Leishmania major | trypanothione reductase | 0.0053672 | 0.0113539 | 0.015465 |
Toxoplasma gondii | thioredoxin reductase | 0.0053672 | 0.0113539 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.00185989 | 0.0013659 | 0.5 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.00185989 | 0.0013659 | 0.120302 |
Brugia malayi | Animal haem peroxidase family protein | 0.00427222 | 0.00823565 | 0.00823565 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.00185989 | 0.0013659 | 0.120302 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0053672 | 0.0113539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0053672 | 0.0113539 | 0.0113539 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.00185989 | 0.0013659 | 0.120302 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.00185989 | 0.0013659 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00427222 | 0.00823565 | 0.00823565 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0053672 | 0.0113539 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0053672 | 0.0113539 | 0.0113539 |
Treponema pallidum | hypothetical protein | 0.0652096 | 0.181771 | 1 |
Schistosoma mansoni | peroxidasin | 0.00427222 | 0.00823565 | 0.725358 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.00185989 | 0.0013659 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.00366822 | 0.00651562 | 0.00651562 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.228649 | 0.647211 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.352532 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.00427222 | 0.00823565 | 0.00823565 |
Loa Loa (eye worm) | hypothetical protein | 0.123883 | 0.348859 | 0.348859 |
Onchocerca volvulus | 0.00427222 | 0.00823565 | 0.00823565 | |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.00185989 | 0.0013659 | 0.0013659 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0053672 | 0.0113539 | 0.015465 |
Onchocerca volvulus | 0.00427222 | 0.00823565 | 0.00823565 | |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.352532 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.00185989 | 0.0013659 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00427222 | 0.00823565 | 0.00823565 |
Onchocerca volvulus | Peroxidasin homolog | 0.00427222 | 0.00823565 | 0.00823565 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.00366822 | 0.00651562 | 0.00651562 |
Onchocerca volvulus | 0.00427222 | 0.00823565 | 0.00823565 | |
Onchocerca volvulus | Peroxidase homolog | 0.00427222 | 0.00823565 | 0.00823565 |
Trypanosoma cruzi | ferric reductase transmembrane protein, putative | 0.228649 | 0.647211 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0053672 | 0.0113539 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0652096 | 0.181771 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.00427222 | 0.00823565 | 0.00823565 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.00185989 | 0.0013659 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.00427222 | 0.00823565 | 0.00823565 |
Echinococcus multilocularis | peroxidasin | 0.00427222 | 0.00823565 | 0.725358 |
Plasmodium falciparum | thioredoxin reductase | 0.0053672 | 0.0113539 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.00185989 | 0.0013659 | 0.120302 |
Brugia malayi | Animal haem peroxidase family protein | 0.00427222 | 0.00823565 | 0.00823565 |
Echinococcus granulosus | peroxidasin | 0.00427222 | 0.00823565 | 0.725358 |
Trichomonas vaginalis | glutathione reductase, putative | 0.00185989 | 0.0013659 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Schistosoma mansoni | peroxidasin | 0.00427222 | 0.00823565 | 0.725358 |
Trypanosoma brucei | ferric reductase transmembrane protein, putative | 0.228649 | 0.647211 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0053672 | 0.0113539 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00427222 | 0.00823565 | 0.00823565 |
Brugia malayi | Thioredoxin reductase | 0.0053672 | 0.0113539 | 0.0113539 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Cytotoxicity (functional) | % | In Vitro evaluation of the compound for the percentage of activity towards T. brucei at 12.5 microM Concentration; Toxic upon mouse primary peritoneal macrophages | ChEMBL. | 10893302 |
Cytotoxicity (functional) | T 0 % | In Vitro evaluation of the compound for the percentage of activity towards T. brucei at 12.5 microM Concentration; Toxic upon mouse primary peritoneal macrophages | ChEMBL. | 10893302 |
Cytotoxicity (functional) | T 0 % | Percentage of activity against T. cruzi at 12.5 microM; Toxic upon mouse primary peritoneal macrophages | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 0 % | Percentage of activity against T. cruzi at 3.13 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 0 % | Percentage of activity against T. cruzi at 1.56 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | T 0 % | Percentage of activity against L. infantum at 12.5 microM Concentration; Toxic upon mouse primary peritoneal macrophages | ChEMBL. | 10893302 |
Cytotoxicity (functional) | T 0 % | Percentage of activity against L. infantum at 6.25 microM; Toxic upon mouse primary peritoneal macrophages | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 0 % | Percentage of activity against L. infantum at 3.13 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 0 % | Percentage of activity against L. infantum at 1.56 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 0 % | Percentage of activity against T. cruzi at 3.13 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 0 % | Percentage of activity against T. cruzi at 1.56 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 0 % | Percentage of activity against L. infantum at 3.13 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 0 % | Percentage of activity against L. infantum at 1.56 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 31 % | Cytotoxicity on MRC-5 cells at 3.13 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 31 % | Cytotoxicity on MRC-5 cells at 3.13 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 40 % | Percentage of activity against T. cruzi at 6.25 microM Concentration | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 40 % | Percentage of activity against T. cruzi at 6.25 microM Concentration | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 41 % | Cytotoxicity on MRC-5 cells at 6.25 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 41 % | Cytotoxicity on MRC-5 cells at 6.25 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 71 % | Cytotoxicity on MRC-5 cells at 12.5 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 71 % | Cytotoxicity on MRC-5 cells at 12.5 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 100 % | Cytotoxicity on MRC-5 cells at 25 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 100 % | Percentage of activity against T. brucei at 6.25 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 100 % | Percentage of activity against T. brucei at 3.13 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 100 % | Percentage of activity against T. brucei at 1.56 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 100 % | Cytotoxicity on MRC-5 cells at 25 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 100 % | Percentage of activity against T. brucei at 6.25 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 100 % | Percentage of activity against T. brucei at 3.13 microM | ChEMBL. | 10893302 |
Cytotoxicity (functional) | = 100 % | Percentage of activity against T. brucei at 1.56 microM | ChEMBL. | 10893302 |
IC50 (functional) | = 440 nM | In vitro sensitivity of Plasmodium falciparum FcB1R Strain | ChEMBL. | 10893302 |
IC50 (functional) | = 440 nM | In vitro sensitivity of Plasmodium falciparum FcB1R Strain | ChEMBL. | 10893302 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 10893302 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.