Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | jun protein | 0.0086 | 0.3032 | 0.7269 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1124 | 0.1892 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.2136 | 0.3595 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.2136 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.2136 | 0.4634 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0108 | 0.4014 | 0.8342 |
Brugia malayi | hypothetical protein | 0.0067 | 0.2204 | 0.2204 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0108 | 0.4014 | 0.8342 |
Toxoplasma gondii | thioredoxin reductase | 0.0047 | 0.1295 | 0.5 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0888 | 0.1927 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0066 | 0.2136 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0086 | 0.3032 | 0.3032 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1124 | 0.2695 |
Brugia malayi | Thioredoxin reductase | 0.0047 | 0.1295 | 0.1295 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.012 | 0.4554 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.2136 | 0.2136 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0108 | 0.4014 | 0.8342 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0066 | 0.2136 | 1 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.2309 | 0.3887 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0047 | 0.1295 | 0.1295 |
Schistosoma mansoni | jun-related protein | 0.007 | 0.2309 | 0.3887 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0888 | 0.2129 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.012 | 0.4554 | 1 |
Brugia malayi | glutathione reductase | 0.0047 | 0.1295 | 0.1295 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.2136 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1124 | 0.1124 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0121 | 0.4608 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0066 | 0.2136 | 0.2136 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.2136 | 0.5119 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0121 | 0.4608 | 0.7758 |
Onchocerca volvulus | 0.0067 | 0.2204 | 1 | |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0047 | 0.1295 | 0.3105 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0111 | 0.4172 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0241 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.012 | 0.4554 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0086 | 0.3032 | 0.7269 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.012 | 0.4554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2926 | 0.2926 |
Plasmodium falciparum | thioredoxin reductase | 0.0047 | 0.1295 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0086 | 0.3032 | 0.658 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0108 | 0.4014 | 0.8342 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0047 | 0.1295 | 0.2811 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0047 | 0.1295 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1124 | 0.2439 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1124 | 0.1892 |
Echinococcus granulosus | jun protein | 0.0086 | 0.3032 | 0.658 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.2136 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0108 | 0.4014 | 0.8342 |
Plasmodium falciparum | glutathione reductase | 0.0047 | 0.1295 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0047 | 0.1295 | 0.1295 |
Plasmodium vivax | glutathione reductase, putative | 0.0047 | 0.1295 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0108 | 0.4014 | 0.8342 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.581 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.