Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | furin | 0.0316 | 0.5631 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0192 | 0.1997 | 0.5 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.0199 | 0.2188 | 0.0526 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0192 | 0.1997 | 0.5 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0129 | 0.0141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.5631 | 1 |
Echinococcus multilocularis | 0.0255 | 0.3839 | 1 | |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.0199 | 0.2188 | 0.1038 |
Trypanosoma brucei | beta lactamase | 0.0129 | 0.0141 | 0.5 |
Brugia malayi | celfurPC protein | 0.0255 | 0.3839 | 0.4795 |
Brugia malayi | endoprotease bli-4 precursor | 0.0316 | 0.5631 | 1 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.0316 | 0.5631 | 1 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0268 | 0.4232 | 1 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0268 | 0.4232 | 0.4149 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0316 | 0.5631 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.