Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.1074 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0209 | 1 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0182 | 0.1195 | 0.1195 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0182 | 0.1195 | 0.1195 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
FC (functional) | = 1.68 | Agonist activity at human PPARdelta in human HepG2 cells co-transfected with PPRE3-TK-luc assessed as induction of transactivation activity at 10 uM by luciferase reporter gene assay relative to control | ChEMBL. | 21195611 |
FC (functional) | = 1.75 | Agonist activity at human PPARgamma in human HepG2 cells co-transfected with PPRE3-TK-luc assessed as induction of transactivation activity at 0.2 uM by luciferase reporter gene assay relative to control | ChEMBL. | 21195611 |
FC (functional) | = 3.61 | Agonist activity at human PPARalpha in human HepG2 cells co-transfected with PPRE3-TK-luc assessed as induction of transactivation activity at 10 uM by luciferase reporter gene assay relative to control | ChEMBL. | 21195611 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.