Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cation transporter family protein | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | 484 aa | 469 aa | 28.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.2854 | 0.2854 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0212 | 0.303 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0157 | 0.1768 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0212 | 0.303 | 0.1533 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0157 | 0.1768 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0157 | 0.1768 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0212 | 0.303 | 0.1533 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0511 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0106 | 0.0584 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0511 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.3396 | 0.3396 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0212 | 0.303 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0511 | 1 | 1 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0511 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0157 | 0.1768 | 0.5835 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0431 | 0.8144 | 0.7745 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0212 | 0.303 | 0.303 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0157 | 0.1768 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0212 | 0.303 | 0.1533 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0157 | 0.1768 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.7 nM | Binding affinity to human 5HT3A receptor | ChEMBL. | 21146988 |
Ki (binding) | = 1 nM | BindingDB_Patents: Radioligand Binding Assay. The relative affinity of the various compounds for the human 5-HT3 receptor was measured in a radioligand binding assay, using a scintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Ki (binding) | = 1 nM | BindingDB_Patents: Radioligand Binding Assay. The relative affinity of the various compounds for the human 5-HT3 receptor was measured in a radioligand binding assay, using a scintillation proximity assay (SPA) format. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.