Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0337 | 0.6402 | 1 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0273 | 0.4173 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0168 | 0.0502 | 0.0784 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0337 | 0.6402 | 0.6212 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0153 | 0 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0337 | 0.6402 | 0.632 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0168 | 0.0502 | 0.0784 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0168 | 0.0502 | 0.0784 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0153 | 0 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0435 | 0.9839 | 1 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.044 | 1 | 1 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0337 | 0.6402 | 1 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0168 | 0.0502 | 0.0784 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.044 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0337 | 0.6402 | 0.6212 |
Echinococcus granulosus | prolyl endopeptidase | 0.0337 | 0.6402 | 0.6212 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0435 | 0.9839 | 0.983 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0435 | 0.9839 | 1 |
Trypanosoma brucei | prolyl endopeptidase | 0.0337 | 0.6402 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0435 | 0.9839 | 0.983 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0435 | 0.9839 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0435 | 0.9839 | 0.983 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0337 | 0.6402 | 0.6212 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0168 | 0.0502 | 0.0784 |
Toxoplasma gondii | prolyl endopeptidase | 0.0337 | 0.6402 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.06 uM | Antiproliferative activity against human A549 cells after 3 days by sulforhodamine B assay | ChEMBL. | 21284385 |
GI50 (functional) | = 0.08 uM | Antiproliferative activity against human KB cells after 3 days by sulforhodamine B assay | ChEMBL. | 21284385 |
GI50 (functional) | = 0.11 uM | Antiproliferative activity against human MCF7 cells after 3 days by sulforhodamine B assay | ChEMBL. | 21284385 |
GI50 (functional) | = 0.13 uM | Antiproliferative activity against human HepG2 cells after 3 days by sulforhodamine B assay | ChEMBL. | 21284385 |
GI50 (functional) | = 0.13 uM | Antiproliferative activity against human HCT8 cells after 3 days by sulforhodamine B assay | ChEMBL. | 21284385 |
GI50 (functional) | = 0.16 uM | Antiproliferative activity against human PC3 cells after 3 days by sulforhodamine B assay | ChEMBL. | 21284385 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.