Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | neuropeptide receptor | 0.0758 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0648 | 0.8374 | 1 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0758 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0081 | 0 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0081 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0081 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0081 | 0 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0081 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0648 | 0.8374 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0648 | 0.8374 | 1 |
Onchocerca volvulus | Deterin homolog | 0.0648 | 0.8374 | 0.5 |
Onchocerca volvulus | 0.0648 | 0.8374 | 0.5 | |
Echinococcus multilocularis | neuropeptide receptor | 0.0758 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0648 | 0.8374 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.