Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0534 | 0.2935 | 0.8059 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0251 | 0.124 | 0.3405 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0098 | 0.0326 | 0.0336 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0529 | 0.2904 | 1 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0112 | 0.0408 | 0.1119 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0385 | 0.2045 | 0.5614 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0112 | 0.0408 | 0.5 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0112 | 0.0408 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0529 | 0.2904 | 0.4248 |
Brugia malayi | Matrixin family protein | 0.1187 | 0.6836 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.2338 | 0.3322 |
Brugia malayi | Hemopexin family protein | 0.0534 | 0.2935 | 0.4293 |
Brugia malayi | Matrixin family protein | 0.0435 | 0.2338 | 0.342 |
Echinococcus multilocularis | geminin | 0.039 | 0.2074 | 0.2074 |
Loa Loa (eye worm) | matrixin family protein | 0.1187 | 0.6836 | 1 |
Onchocerca volvulus | 0.0435 | 0.2338 | 0.0616 | |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0385 | 0.2045 | 0.2886 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | snurportin 1 | 0.0361 | 0.19 | 0.19 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0964 | 0.5501 | 0.7261 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0112 | 0.0408 | 0.0408 |
Schistosoma mansoni | hypothetical protein | 0.0361 | 0.19 | 0.5217 |
Echinococcus granulosus | geminin | 0.039 | 0.2074 | 0.2074 |
Loa Loa (eye worm) | hypothetical protein | 0.0653 | 0.3642 | 0.5258 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0529 | 0.2904 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.1182 | 0.6805 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0361 | 0.19 | 0.2672 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.2338 | 0.3322 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0112 | 0.0408 | 0.0408 |
Brugia malayi | Matrixin family protein | 0.0435 | 0.2338 | 0.342 |
Onchocerca volvulus | Matrilysin homolog | 0.0435 | 0.2338 | 0.0616 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0385 | 0.2045 | 0.2991 |
Brugia malayi | Matrixin family protein | 0.0435 | 0.2338 | 0.342 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0098 | 0.0326 | 0.0326 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0112 | 0.0408 | 0.0408 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0435 | 0.2338 | 0.3322 |
Mycobacterium ulcerans | hydrolase | 0.0529 | 0.2904 | 0.5 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0098 | 0.0326 | 0.0477 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.01 | 0.0146 |
Onchocerca volvulus | 0.0534 | 0.2935 | 0.187 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0385 | 0.2045 | 0.2886 |
Loa Loa (eye worm) | matrixin family protein | 0.0964 | 0.5501 | 0.8018 |
Brugia malayi | RNA, U transporter 1 | 0.0096 | 0.0316 | 0.0462 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.1716 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0435 | 0.2338 | 0.342 |
Echinococcus multilocularis | snurportin 1 | 0.0361 | 0.19 | 0.19 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0385 | 0.2045 | 0.2045 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.01 | 0.0146 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0098 | 0.0326 | 0.0326 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0385 | 0.2045 | 0.2045 |
Brugia malayi | Protein kinase domain containing protein | 0.0385 | 0.2045 | 0.2991 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0408 | 0.0456 |
Loa Loa (eye worm) | hypothetical protein | 0.0529 | 0.2904 | 0.4162 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.2074 | 0.5694 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0112 | 0.0408 | 0.0408 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0653 | 0.3642 | 1 |
Schistosoma mansoni | hypothetical protein | 0.039 | 0.2074 | 0.5694 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.