Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1815 | 1 | 1 | |
Plasmodium falciparum | cytochrome b | 0.0511 | 0.263 | 0.5 |
Toxoplasma gondii | apocytochrome b, putative | 0.0511 | 0.263 | 1 |
Echinococcus granulosus | cytochrome B | 0.0511 | 0.263 | 1 |
Brugia malayi | Fli-1 protein | 0.0224 | 0.1006 | 0.6682 |
Brugia malayi | Ets-domain containing protein | 0.0074 | 0.0159 | 0.1053 |
Loa Loa (eye worm) | fli-1 protein | 0.0224 | 0.1006 | 0.6682 |
Schistosoma mansoni | cytochrome b | 0.0511 | 0.263 | 1 |
Schistosoma mansoni | cytochrome b | 0.0312 | 0.1506 | 0.5452 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.0202 | 1 |
Loa Loa (eye worm) | cytochrome b | 0.0312 | 0.1506 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.0202 | 1 |
Toxoplasma gondii | cytochrome b | 0.0511 | 0.263 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.0202 | 0.0176 |
Mycobacterium ulcerans | ubiquinol-cytochrome C reductase QcrB | 0.1815 | 1 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.0202 | 0.0176 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.0202 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0074 | 0.0159 | 0.1053 |
Mycobacterium tuberculosis | Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) | 0.1815 | 1 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.002 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0098 | 0.0652 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0081 | 0.0202 | 0.1342 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.0202 | 0.0176 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0511 | 0.263 | 0.5 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0074 | 0.0159 | 0.1053 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.0202 | 1 |
Schistosoma mansoni | ets-related | 0.0224 | 0.1006 | 0.343 |
Brugia malayi | Heterochromatin protein 1 | 0.0081 | 0.0202 | 0.1342 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.002 | 0.0969 |
Plasmodium vivax | cytochrome b | 0.0511 | 0.263 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.0202 | 0.0176 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0049 | 0.002 | 0.002 |
Brugia malayi | cytochrome b | 0.0312 | 0.1506 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.6 uM | Antagonist activity at CCR2 in human THP1 cells assessed as inhibition of CCL2-induced chemotaxis | ChEMBL. | 21341682 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.