Detailed information for compound 1494404

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.437 | Formula: C19H28N2O4
  • H donors: 2 H acceptors: 4 LogP: 3.83 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC[C@@H](C(=O)[C@H](C(C)C)NC(=O)c1ccccc1)CN(C=O)O
  • InChi: 1S/C19H28N2O4/c1-4-5-9-16(12-21(25)13-22)18(23)17(14(2)3)20-19(24)15-10-7-6-8-11-15/h6-8,10-11,13-14,16-17,25H,4-5,9,12H2,1-3H3,(H,20,24)/t16-,17+/m1/s1
  • InChiKey: YMADTYRFMLHXJV-SJORKVTESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) Peptide deformylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium ulcerans peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium yoelii polypeptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium knowlesi peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) Get druggable targets OG5_128237 All targets in OG5_128237
Wolbachia endosymbiont of Brugia malayi peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Chlamydia trachomatis peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium vivax peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Treponema pallidum polypeptide deformylase (def) Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium berghei peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Neospora caninum Peptide deformylase, related Get druggable targets OG5_128237 All targets in OG5_128237
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128237 All targets in OG5_128237
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis polypeptide deformylase-like protein, putative Peptide deformylase   168 aa 142 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0026 0.0268 0.5
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0268 1
Plasmodium falciparum peptide deformylase 0.0279 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus serotonin receptor 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Brugia malayi Serotonin receptor 0.0026 0.0268 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0268 1
Echinococcus granulosus g protein coupled receptor 0.0026 0.0268 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0268 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0268 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0268 1
Brugia malayi G-protein coupled receptor 0.0026 0.0268 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0268 1
Leishmania major polypeptide deformylase-like protein, putative 0.0106 0.3359 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0268 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0268 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Brugia malayi Dopamine receptor 0.0026 0.0268 1
Schistosoma mansoni biogenic amine receptor 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus granulosus g protein coupled receptor 0.0026 0.0268 1
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0268 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0268 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0268 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0268 1
Treponema pallidum polypeptide deformylase (def) 0.0279 1 0.5
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0268 1
Echinococcus granulosus g protein coupled receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Plasmodium vivax peptide deformylase, putative 0.0279 1 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Brugia malayi neuropeptide F receptor 0.0026 0.0268 1
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi sulfakinin receptor protein 0.0026 0.0268 1
Schistosoma mansoni opsin-like receptor 0.0026 0.0268 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Brugia malayi putative neuropeptide receptor 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0268 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0268 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0268 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0268 1
Schistosoma mansoni histamine h1 receptor 0.0026 0.0268 1
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0268 1
Schistosoma mansoni amine GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi GnHR receptor homolog 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Brugia malayi G-protein coupled receptor 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0268 1
Brugia malayi Serotonin receptor 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus neuropeptide receptor 0.0026 0.0268 1
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Schistosoma mansoni opsin-like receptor 0.0026 0.0268 1
Schistosoma mansoni amine GPCR 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Giardia lamblia DINP protein human, muc B family 0.0019 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0268 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0 0.5
Schistosoma mansoni adenoreceptor 0.0026 0.0268 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0268 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0268 1
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0268 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Schistosoma mansoni hypothetical protein 0.0026 0.0268 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi Melatonin receptor type 1A 0.0026 0.0268 1
Schistosoma mansoni amine GPCR 0.0026 0.0268 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0 0.5
Schistosoma mansoni hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni amine GPCR 0.0026 0.0268 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0268 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0268 1
Echinococcus multilocularis somatostatin receptor 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Echinococcus granulosus fmrfamide receptor 0.0026 0.0268 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis serotonin receptor 0.0026 0.0268 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0268 1
Brugia malayi AKH receptor 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0268 1
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0268 1
Schistosoma mansoni hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0268 1
Schistosoma mansoni opsin-like receptor 0.0026 0.0268 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0268 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0268 1
Brugia malayi Dopamine receptor protein 1 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0268 1
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0279 1 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0268 1
Brugia malayi G protein-coupled receptor 0.0026 0.0268 1
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0268 1
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.3359 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0268 1
Brugia malayi larval opioid receptor 0.0026 0.0268 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0268 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0268 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0 0.5
Onchocerca volvulus 0.0026 0.0268 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0268 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0268 1
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0268 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0268 1
Toxoplasma gondii hypothetical protein 0.0279 1 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0268 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0268 0.5
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.3359 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus somatostatin receptor 0.0026 0.0268 1
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0268 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0268 1
Echinococcus multilocularis serotonin receptor 0.0026 0.0268 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.3359 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0268 1
Echinococcus multilocularis sex peptide receptor 0.0026 0.0268 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Schistosoma mansoni hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0268 1
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0279 1 1
Schistosoma mansoni biogenic amine receptor 0.0026 0.0268 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0279 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni amine GPCR 0.0026 0.0268 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0268 1
Schistosoma mansoni biogenic amine receptor 0.0026 0.0268 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0268 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0268 1
Echinococcus granulosus neuropeptide receptor 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus sex peptide receptor 0.0026 0.0268 1
Echinococcus granulosus orexin receptor type 2 0.0026 0.0268 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0268 1
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0268 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0268 1
Trypanosoma brucei Peptide deformylase 2 0.0106 0.3359 1
Brugia malayi Dopamine receptor protein 2 0.0026 0.0268 1
Schistosoma mansoni myosin xvIII 0.0026 0.0268 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0268 1
Brugia malayi ORL1-like opioid receptor 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0268 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0268 1
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Mycobacterium ulcerans peptide deformylase 0.0279 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0268 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.3359 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0268 1
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0268 1
Trypanosoma brucei Polypeptide deformylase 1 0.0106 0.3359 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0268 1
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0268 1
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0268 1
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0268 1
Echinococcus granulosus allatostatin A receptor 0.0026 0.0268 1
Brugia malayi neuropeptide F receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0268 1
Echinococcus granulosus hypothetical protein 0.0026 0.0268 1
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0268 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0268 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0268 1
Brugia malayi RE15519p 0.0026 0.0268 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0268 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0268 1
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 51 nM Inhibition of Pseudomonas aeruginosa peptide deformylase after 10 mins by fluorescence assay ChEMBL. 21146987

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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