Detailed information for compound 1494404

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.437 | Formula: C19H28N2O4
  • H donors: 2 H acceptors: 4 LogP: 3.83 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC[C@@H](C(=O)[C@H](C(C)C)NC(=O)c1ccccc1)CN(C=O)O
  • InChi: 1S/C19H28N2O4/c1-4-5-9-16(12-21(25)13-22)18(23)17(14(2)3)20-19(24)15-10-7-6-8-11-15/h6-8,10-11,13-14,16-17,25H,4-5,9,12H2,1-3H3,(H,20,24)/t16-,17+/m1/s1
  • InChiKey: YMADTYRFMLHXJV-SJORKVTESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) Peptide deformylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) Get druggable targets OG5_128237 All targets in OG5_128237
Wolbachia endosymbiont of Brugia malayi peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium yoelii polypeptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium vivax peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Treponema pallidum polypeptide deformylase (def) Get druggable targets OG5_128237 All targets in OG5_128237
Chlamydia trachomatis peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium knowlesi peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) Get druggable targets OG5_128237 All targets in OG5_128237
Neospora caninum Peptide deformylase, related Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium berghei peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium falciparum peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium ulcerans peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis polypeptide deformylase-like protein, putative Peptide deformylase   168 aa 142 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus neuropeptide receptor 0.0026 0.0268 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0268 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0268 1
Schistosoma mansoni hypothetical protein 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0268 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus granulosus neuropeptide receptor 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0268 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0268 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0026 0.0268 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0268 1
Brugia malayi Dopamine receptor protein 1 0.0026 0.0268 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0026 0.0268 0.5
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0268 1
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0268 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0268 1
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0268 1
Schistosoma mansoni hypothetical protein 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Brugia malayi neuropeptide F receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi Dopamine receptor protein 2 0.0026 0.0268 1
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0268 1
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0279 1 0.5
Brugia malayi sulfakinin receptor protein 0.0026 0.0268 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.3359 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0268 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0268 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0268 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Brugia malayi G-protein coupled receptor 0.0026 0.0268 1
Brugia malayi Melatonin receptor type 1A 0.0026 0.0268 1
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0268 1
Echinococcus granulosus hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Schistosoma mansoni amine GPCR 0.0026 0.0268 1
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0268 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0268 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Echinococcus granulosus allatostatin A receptor 0.0026 0.0268 1
Mycobacterium ulcerans peptide deformylase 0.0279 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni biogenic amine receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus serotonin receptor 0.0026 0.0268 1
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0268 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0268 1
Echinococcus granulosus g protein coupled receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0268 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0268 1
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus g protein coupled receptor 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0268 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0268 1
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0268 1
Echinococcus granulosus fmrfamide receptor 0.0026 0.0268 1
Schistosoma mansoni histamine h1 receptor 0.0026 0.0268 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0 0.5
Schistosoma mansoni neuropeptide receptor 0.0026 0.0268 1
Echinococcus granulosus sex peptide receptor 0.0026 0.0268 1
Brugia malayi AKH receptor 0.0026 0.0268 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0268 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0268 1
Schistosoma mansoni biogenic amine receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0268 1
Schistosoma mansoni opsin-like receptor 0.0026 0.0268 1
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.3359 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Brugia malayi hypothetical protein 0.0026 0.0268 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0268 1
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0279 1 1
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0279 1 0.5
Treponema pallidum polypeptide deformylase (def) 0.0279 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni opsin-like receptor 0.0026 0.0268 1
Plasmodium vivax peptide deformylase, putative 0.0279 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0268 1
Schistosoma mansoni amine GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Toxoplasma gondii hypothetical protein 0.0279 1 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0268 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Brugia malayi RE15519p 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0268 1
Brugia malayi G-protein coupled receptor 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0268 1
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0268 1
Brugia malayi G protein-coupled receptor 0.0026 0.0268 1
Trypanosoma brucei Peptide deformylase 2 0.0106 0.3359 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.3359 1
Onchocerca volvulus 0.0026 0.0268 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0268 1
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0268 1
Schistosoma mansoni biogenic amine receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0268 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.3359 1
Echinococcus multilocularis serotonin receptor 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0268 1
Schistosoma mansoni hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0268 1
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0268 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0268 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0268 1
Leishmania major polypeptide deformylase-like protein, putative 0.0106 0.3359 1
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0268 1
Schistosoma mansoni amine GPCR 0.0026 0.0268 1
Brugia malayi Serotonin receptor 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi GnHR receptor homolog 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni opsin-like receptor 0.0026 0.0268 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0268 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0268 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0268 1
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0268 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0268 1
Brugia malayi larval opioid receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0268 1
Schistosoma mansoni hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0268 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Schistosoma mansoni amine GPCR 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis somatostatin receptor 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0268 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0268 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0268 1
Echinococcus multilocularis serotonin receptor 0.0026 0.0268 1
Brugia malayi hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus g protein coupled receptor 0.0026 0.0268 1
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0268 1
Echinococcus granulosus somatostatin receptor 0.0026 0.0268 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0268 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0268 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0268 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi Serotonin receptor 0.0026 0.0268 1
Brugia malayi putative neuropeptide receptor 0.0026 0.0268 1
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0268 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0268 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0268 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0268 1
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0268 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0268 1
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0268 1
Plasmodium falciparum peptide deformylase 0.0279 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0268 1
Brugia malayi neuropeptide F receptor 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Trypanosoma brucei Polypeptide deformylase 1 0.0106 0.3359 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0268 1
Giardia lamblia DINP protein human, muc B family 0.0019 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Brugia malayi Dopamine receptor 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0268 1
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0268 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0268 1
Schistosoma mansoni neuropeptide receptor 0.0026 0.0268 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0268 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0268 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0268 1
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0268 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0268 1
Schistosoma mansoni amine GPCR 0.0026 0.0268 1
Echinococcus granulosus orexin receptor type 2 0.0026 0.0268 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0268 1
Echinococcus multilocularis sex peptide receptor 0.0026 0.0268 1
Schistosoma mansoni adenoreceptor 0.0026 0.0268 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0268 1
Schistosoma mansoni myosin xvIII 0.0026 0.0268 1
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0268 1
Brugia malayi ORL1-like opioid receptor 0.0026 0.0268 1
Onchocerca volvulus 0.0026 0.0268 0.5
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0268 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 51 nM Inhibition of Pseudomonas aeruginosa peptide deformylase after 10 mins by fluorescence assay ChEMBL. 21146987

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.