Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | aminopeptidase, putative | 0.0232 | 0.21 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0232 | 0.21 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0232 | 0.21 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0232 | 0.21 | 0.21 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0112 | 0.0393 | 0.0393 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0232 | 0.21 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0232 | 0.21 | 0.21 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0232 | 0.21 | 0.21 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0232 | 0.21 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0232 | 0.21 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0232 | 0.21 | 0.21 |
Loa Loa (eye worm) | hypothetical protein | 0.0375 | 0.4122 | 0.4026 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0232 | 0.21 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0232 | 0.21 | 0.21 |
Loa Loa (eye worm) | aminopeptidase N | 0.0232 | 0.21 | 0.1467 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0232 | 0.21 | 0.21 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0232 | 0.21 | 0.21 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0232 | 0.21 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0232 | 0.21 | 0.21 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0112 | 0.0393 | 0.0393 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0232 | 0.21 | 0.5 |
Onchocerca volvulus | 0.0789 | 1 | 1 | |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0232 | 0.21 | 0.21 |
Loa Loa (eye worm) | hypothetical protein | 0.0707 | 0.8841 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0557 | 0.6705 | 0.7295 |
Echinococcus granulosus | aminopeptidase N | 0.0789 | 1 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0151 | 0.0942 | 0.0942 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0232 | 0.21 | 0.21 |
Echinococcus granulosus | adam 17 protease | 0.0196 | 0.1588 | 0.1588 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0232 | 0.21 | 0.5 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0151 | 0.0942 | 0.4484 |
Echinococcus multilocularis | aminopeptidase N | 0.0789 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0232 | 0.21 | 0.21 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0232 | 0.21 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0232 | 0.21 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0638 | 0.7863 | 0.8762 |
Echinococcus multilocularis | adam 17 protease | 0.0178 | 0.1335 | 0.1335 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0232 | 0.21 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0232 | 0.21 | 0.5 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0232 | 0.21 | 0.21 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0178 | 0.1335 | 0.6358 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 370 uM | Compound was tested for its ability to inhibit the thrombin-induced platelet aggregation in washed human platelets | ChEMBL. | 9873606 |
IC50 (functional) | = 370 uM | Compound was tested for its ability to inhibit the thrombin-induced platelet aggregation in washed human platelets | ChEMBL. | 9873606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.