Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.3138 | 0.3138 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.3138 | 0.3138 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0102 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0102 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.3138 | 0.3138 |
Schistosoma mansoni | tyrosinase precursor | 0.0102 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0102 | 1 | 1 |
Onchocerca volvulus | 0.0102 | 1 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0072 | 0.5036 | 0.5036 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0102 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0072 | 0.5036 | 0.5036 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0102 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0102 | 1 | 1 |
Onchocerca volvulus | 0.0102 | 1 | 0.5 | |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0102 | 1 | 1 |
Onchocerca volvulus | 0.0102 | 1 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.3138 | 0.3138 |
Onchocerca volvulus | 0.0102 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 32.964 uM | PUBCHEM_BIOASSAY: Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504435] | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.