Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate (NMDA) receptor subunit zeta 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate receptor ionotropic, kainate | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glutamate receptor 1 precursor | 0.008 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.008 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0182 | 0.9045 | 1 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0095 | 0.1376 | 0.1521 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0182 | 0.9045 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0087 | 0.0635 | 0.0702 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.008 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0095 | 0.1376 | 0.1521 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Brugia malayi | Glutamate receptor 2 precursor | 0.008 | 0 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0113 | 0.2966 | 0.3279 |
Echinococcus granulosus | glutamate receptor 2 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0098 | 0.159 | 0.1758 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0113 | 0.2966 | 0.3279 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.8 uM | Concentration necessary for 50% inhibition of depolarization induced by 5 microM S-AMPA in mouse cortical wedge preparation | ChEMBL. | 14695840 |
IC50 (functional) | = 0.8 uM | Concentration necessary for 50% inhibition of depolarization induced by 5 microM S-AMPA in mouse cortical wedge preparation | ChEMBL. | 14695840 |
IC50 (binding) | = 1.8 uM | Inhibition concentration towards low-affinity Ionotropic glutamate receptor kainate of rat cortical membranes by using [3H]-KA as radioligand | ChEMBL. | 14695840 |
IC50 (binding) | = 1.8 uM | Inhibition concentration towards low-affinity Ionotropic glutamate receptor kainate of rat cortical membranes by using [3H]-KA as radioligand | ChEMBL. | 14695840 |
IC50 (functional) | = 5.8 uM | Concentration that inhibits 50% S-AMPA stimulated (50 microM) [3H]-norepinephrine release from rat hippocampal synaptosomes | ChEMBL. | 14695840 |
IC50 (binding) | = 9.6 uM | Inhibition concentration towards high-affinity ionotropic glutamate receptor kainate of rat cortical membranes by using [3H]-KA as radioligand | ChEMBL. | 14695840 |
IC50 (binding) | = 9.6 uM | Inhibition concentration towards high-affinity ionotropic glutamate receptor kainate of rat cortical membranes by using [3H]-KA as radioligand | ChEMBL. | 14695840 |
IC50 (functional) | = 29 uM | Concentration giving 50% inhibition of stimulated [3H]-(+)-MK-801 binding in rat cortical membranes incubated with 10 microM glycine | ChEMBL. | 14695840 |
IC50 (functional) | = 60 uM | Concentration necessary for 50% inhibition of depolarization induced by 5 microM NMDA in mouse cortical wedge preparation | ChEMBL. | 14695840 |
IC50 (functional) | = 60 uM | Concentration necessary for 50% inhibition of depolarization induced by 5 microM NMDA in mouse cortical wedge preparation | ChEMBL. | 14695840 |
Ki (binding) | = 0.095 uM | Binding affinity towards ionotropic glutamate receptor (high-affinity) of rat cortical synaptic membranes by using [3H]-AMPA as radioligand | ChEMBL. | 14695840 |
Ki (binding) | = 0.095 uM | Binding affinity towards ionotropic glutamate receptor (high-affinity) of rat cortical synaptic membranes by using [3H]-AMPA as radioligand | ChEMBL. | 14695840 |
Ki (binding) | = 3.6 uM | Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 (high affinity) of rat cortical synaptic membranes by using [3H]-Gly as radioligand | ChEMBL. | 14695840 |
Ki (binding) | = 3.6 uM | Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 (high affinity) of rat cortical synaptic membranes by using [3H]-Gly as radioligand | ChEMBL. | 14695840 |
Ratio (binding) | = 0.19 | Ratio of IC50 of KA low-affinity receptor site to KA high-affinity receptor site | ChEMBL. | 14695840 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 14695840 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.