Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor 55 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0274 | 0 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0274 | 0 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP5 | 0.0537 | 0.609 | 1 |
Plasmodium falciparum | plasmepsin V | 0.0642 | 0.8517 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0274 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0274 | 0 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0706 | 1 | 1 |
Plasmodium vivax | plasmepsin V, putative | 0.0642 | 0.8517 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 11.5 uM | PUBCHEM_BIOASSAY: SAR analysis of selective Agonists of GPR55 using an Image-Based Assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965] | ChEMBL. | No reference |
EC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of agonists of the Cannabinoid Receptor 2 using an Image-Based Assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965] | ChEMBL. | No reference |
EC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of agonists of the Cannabinoid Receptor 1 using an Image-Based Assay - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965] | ChEMBL. | No reference |
EC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of Agonists of the GPR35 Receptor using an Image-Based Assay - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965] | ChEMBL. | No reference |
IC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of antagonists of the Cannabinoid Receptor 1 using an Image-Based Assay - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965] | ChEMBL. | No reference |
IC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of antagonists of the Cannabinoid Receptor 2 using an Image-Based Assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965] | ChEMBL. | No reference |
IC50 (functional) | > 32 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of the GPR35 Receptor using an Image-Based Assay - Set 4. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1961, AID1965] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.