Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | adenosine kinase, putative | adenosine kinase | 345 aa | 337 aa | 35.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1938 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 0.5574 | 0.6789 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0058 | 0.1788 | 0.1788 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0105 | 0.5574 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.0105 | 0.5574 | 0.5574 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1938 | 0.236 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0105 | 0.5574 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0058 | 0.1788 | 0.1788 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.1788 | 0.2177 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.1938 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.1788 | 0.1788 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 0.5574 | 0.6789 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1938 | 0.1938 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0105 | 0.5574 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0058 | 0.1788 | 0.2177 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.821 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | 0.0093 | 0.4614 | 1 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0058 | 0.1788 | 0.2177 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1938 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 0.5574 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0058 | 0.1788 | 0.1788 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0058 | 0.1788 | 0.1788 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.016 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1938 | 0.3477 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1938 | 0.1938 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1938 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0058 | 0.1788 | 0.1788 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1938 | 0.236 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.1788 | 0.1788 |
Schistosoma mansoni | alpha-glucosidase | 0.0138 | 0.821 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.016 | 1 | 1 |
Echinococcus granulosus | adenosine kinase | 0.0105 | 0.5574 | 0.5574 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.016 | 1 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.5574 | 0.5574 |
Brugia malayi | Adenosine kinase-like | 0.0105 | 0.5574 | 0.5574 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 0.5574 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1938 | 0.3477 |
Leishmania major | adenosine kinase, putative | 0.0105 | 0.5574 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3 uM | Inhibition of human adenosine kinase | ChEMBL. | 21319802 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.