Detailed information for compound 1500251

Basic information

Technical information
  • TDR Targets ID: 1500251
  • Name: 1-(4-fluorophenyl)-5-(5-methyl-1,2-oxazol-3-y l)tetrazole
  • MW: 245.213 | Formula: C11H8FN5O
  • H donors: 0 H acceptors: 4 LogP: 1.87 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)n1nnnc1c1noc(c1)C
  • InChi: 1S/C11H8FN5O/c1-7-6-10(14-18-7)11-13-15-16-17(11)9-4-2-8(12)3-5-9/h2-6H,1H3
  • InChiKey: UXBPGXDQCMZJDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-fluorophenyl)-5-(5-methylisoxazol-3-yl)tetrazole
  • 1-(4-fluorophenyl)-5-(5-methyl-3-isoxazolyl)tetrazole
  • 1-(4-fluorophenyl)-5-(5-methyl-1,2-oxazol-3-yl)-1,2,3,4-tetrazole
  • 3-[1-(4-fluorophenyl)-1H-1,2,3,4-tetraazol-5-yl]-5-methylisoxazole
  • MLS000834934
  • Maybridge3_007060
  • SMR000461450
  • ZINC00122735
  • IDI1_018447

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0198 0.0421 0.5
Toxoplasma gondii PAN domain-containing protein 0.0997 0.3592 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0198 0.0421 0.5
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0198 0.0421 0.5
Loa Loa (eye worm) hypothetical protein 0.0198 0.0421 0.0421
Echinococcus multilocularis tissue type plasminogen activator 0.0198 0.0421 0.5
Toxoplasma gondii PAN domain-containing protein 0.0997 0.3592 1
Loa Loa (eye worm) hypothetical protein 0.2611 1 1
Leishmania major hypothetical protein, conserved 0.0198 0.0421 0.5
Brugia malayi Kringle domain containing protein 0.0198 0.0421 0.0421
Toxoplasma gondii kringle domain-containing protein 0.0198 0.0421 0.1172
Brugia malayi Protein kinase domain containing protein 0.0198 0.0421 0.0421
Trypanosoma cruzi hypothetical protein, conserved 0.0198 0.0421 0.5
Onchocerca volvulus 0.0198 0.0421 0.0421
Onchocerca volvulus 0.2611 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0198 0.0421 0.0421
Echinococcus granulosus tissue type plasminogen activator 0.0198 0.0421 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.122 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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