Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0488 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0242 | 0 | 0.5 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0488 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0433 | 0.7743 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0488 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0488 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0488 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0246 | 0.0151 | 0.0151 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0301 | 0.2407 | 0.2407 |
Loa Loa (eye worm) | hypothetical protein | 0.0488 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0488 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0488 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0488 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0301 | 0.2407 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0242 | 0 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0488 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0433 | 0.7743 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0488 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0488 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0488 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0488 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0488 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0488 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0488 | 1 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0488 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0488 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0488 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0488 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0488 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.2 ug ml-1 | Antibacterial activity was determined against gram negative organism, E. coli vogel | ChEMBL. | 1848296 |
MIC (functional) | = 0.2 ug ml-1 | Antibacterial activity was determined against gram negative organism, E. coli vogel | ChEMBL. | 1848296 |
MIC (functional) | = 0.4 ug ml-1 | Antibacterial activity was determined against gram negative organism, E. cloacae MA2646 | ChEMBL. | 1848296 |
MIC (functional) | = 0.4 ug ml-1 | Antibacterial activity was determined against gram negative organism, K. pneumonia MGH-2 | ChEMBL. | 1848296 |
MIC (functional) | = 0.4 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. aureus UC76 | ChEMBL. | 1848296 |
MIC (functional) | = 1.6 ug ml-1 | Antibacterial activity was determined against gram negative organism, P. rettgeri. M1771 | ChEMBL. | 1848296 |
MIC (functional) | = 3.1 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. auerus H228 | ChEMBL. | 1848296 |
MIC (functional) | = 3.1 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. pneumonia SV-1 | ChEMBL. | 1848296 |
MIC (functional) | = 3.1 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. pyogenes C203 | ChEMBL. | 1848296 |
MIC (functional) | = 5 ug ml-1 | Minimum inhibitory concentration against E. coli DNA-gyrase in supercoiling assay | ChEMBL. | 1848296 |
MIC (functional) | = 5 ug ml-1 | Minimum inhibitory concentration against E. coli DNA-gyrase in supercoiling assay | ChEMBL. | 1848296 |
MIC (functional) | = 6.3 ug ml-1 | Antibacterial activity was determined against gram negative organism, P. aeruginosa UI-18 | ChEMBL. | 1848296 |
MIC (functional) | = 6.3 ug ml-1 | Antibacterial activity was determined against gram positive organism, S. faecalis MGH-2 | ChEMBL. | 1848296 |
Ratio (functional) | = 0.79 | MIC ratio measured as the mean MICs of gram-negative bacteria | ChEMBL. | 1848296 |
Ratio (functional) | = 2.37 | MIC ratio measured as the mean MICs of gram-positive bacteria | ChEMBL. | 1848296 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.