Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0152 | 0.0401 |
Brugia malayi | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3784 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Onchocerca volvulus | Peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0152 | 0.0152 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0903 | 0.2387 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.1261 | 0.1261 |
Onchocerca volvulus | Peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0813 | 0.2147 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0152 | 0.0152 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0463 | 1 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0181 | 0.3784 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0463 | 1 | 1 |
Toxoplasma gondii | cytochrome b | 0.0128 | 0.2617 | 1 |
Schistosoma mansoni | peroxidasin | 0.0177 | 0.3712 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0903 | 0.2387 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0128 | 0.2617 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | peroxidasin | 0.0177 | 0.3712 | 0.3712 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Plasmodium vivax | cytochrome b | 0.0128 | 0.2617 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0128 | 0.2617 | 0.7049 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0152 | 0.0401 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | cytochrome b | 0.0128 | 0.2617 | 0.6914 |
Plasmodium falciparum | cytochrome b | 0.0128 | 0.2617 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0903 | 0.2387 |
Echinococcus multilocularis | peroxidasin | 0.0177 | 0.3712 | 0.3712 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0903 | 0.2387 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0152 | 0.0401 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0813 | 0.0813 |
Brugia malayi | cytochrome b | 0.0128 | 0.2617 | 0.6914 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0813 | 0.0813 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | RNA binding protein | 0.0066 | 0.1261 | 0.3332 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | Peroxidasin homolog | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | cytochrome b | 0.0128 | 0.2617 | 0.7049 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.1261 | 0.3332 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0463 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0813 | 0.0813 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | cytochrome B | 0.0128 | 0.2617 | 0.2617 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.1261 | 0.1261 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0555 | 0.1468 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0555 | 0.1468 |
Brugia malayi | N-terminal motif family protein | 0.0181 | 0.3784 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.1261 | 0.3332 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Onchocerca volvulus | Dual oxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.1261 | 0.3332 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.1261 | 0.3332 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.1261 | 0.3332 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0152 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | peroxidasin | 0.0177 | 0.3712 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0152 | 0.0152 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0813 | 0.2147 |
Brugia malayi | Blistered cuticle protein 3 | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0555 | 0.1496 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0813 | 0.0813 |
Toxoplasma gondii | apocytochrome b, putative | 0.0128 | 0.2617 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0152 | 0.0152 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 428.5 nM | Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
IC50 (functional) | = 1298.1 nM | Antimalarial activity against chloroquine-,pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
IC50 (functional) | = 2605.1 nM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 21316974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.