Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.6166 | 0.6166 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0279 | 0.6166 | 0.5 |
Brugia malayi | Pyruvate kinase, alpha/beta domain containing protein | 0.0121 | 0.1164 | 0.1164 |
Echinococcus multilocularis | pyruvate kinase | 0.0316 | 0.7331 | 0.5671 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0279 | 0.6166 | 0.6166 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 37.6 % | Inhibition of human erythrocytes acetylcholinesterase after 15 mins at 250 uM relative to control | ChEMBL. | 21189039 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.