Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0128 | 0.2617 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0152 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0152 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Brugia malayi | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | RNA binding protein | 0.0066 | 0.1261 | 0.3332 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Schistosoma mansoni | peroxidasin | 0.0177 | 0.3712 | 1 |
Brugia malayi | N-terminal motif family protein | 0.0181 | 0.3784 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0903 | 0.2387 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Toxoplasma gondii | apocytochrome b, putative | 0.0128 | 0.2617 | 1 |
Toxoplasma gondii | cytochrome b | 0.0128 | 0.2617 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | cytochrome b | 0.0128 | 0.2617 | 0.6914 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0152 | 0.0401 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.1261 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0555 | 0.1468 |
Brugia malayi | Blistered cuticle protein 3 | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0555 | 0.1468 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0903 | 0.2387 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0152 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | 0.0177 | 0.3712 | 0.9809 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.1261 | 0.3332 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0813 | 0.0813 |
Brugia malayi | cytochrome b | 0.0128 | 0.2617 | 0.6914 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Echinococcus granulosus | cytochrome B | 0.0128 | 0.2617 | 0.2617 |
Schistosoma mansoni | peroxidasin | 0.0177 | 0.3712 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0152 | 0.0152 |
Schistosoma mansoni | cytochrome b | 0.0128 | 0.2617 | 0.7049 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0177 | 0.3712 | 0.9809 |
Plasmodium falciparum | cytochrome b | 0.0128 | 0.2617 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.1261 | 0.1261 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0181 | 0.3784 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | Dual oxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Echinococcus granulosus | peroxidasin | 0.0177 | 0.3712 | 0.3712 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0152 | 0.0152 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0152 | 0.0409 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0903 | 0.2387 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0813 | 0.0813 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Onchocerca volvulus | Peroxidase homolog | 0.0177 | 0.3712 | 0.9809 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0152 | 0.0401 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0813 | 0.2147 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0152 | 0.0152 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0152 | 0.0401 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.1261 | 0.3332 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0813 | 0.2147 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.1261 | 0.3332 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0555 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0903 | 0.2387 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0813 | 0.0813 |
Plasmodium vivax | cytochrome b | 0.0128 | 0.2617 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0813 | 0.2189 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0152 | 0.0401 |
Brugia malayi | Peroxidasin | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.1261 | 0.3332 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1261 | 0.3397 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.3784 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0177 | 0.3712 | 0.3712 |
Onchocerca volvulus | Peroxidasin homolog | 0.0177 | 0.3712 | 0.9809 |
Schistosoma mansoni | cytochrome b | 0.0128 | 0.2617 | 0.7049 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.1261 | 0.3332 |
Onchocerca volvulus | Peroxidasin homolog | 0.0177 | 0.3712 | 0.9809 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0813 | 0.0813 |
Brugia malayi | Animal haem peroxidase family protein | 0.0177 | 0.3712 | 0.9809 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.3712 | 0.9809 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 434.6 nM | Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
IC50 (functional) | = 495.1 nM | Antimalarial activity against chloroquine-,pyrimethamine-resistant Plasmodium falciparum W2 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
IC50 (functional) | = 688.9 nM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of [3H]hypoxanthine incorporation after 96 hrs by microtiter plate scintillation counting | ChEMBL. | 21316974 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 21316974 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.