Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | peptide deformylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0228 | 0.6244 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0279 | 0.8331 | 0.5 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0228 | 0.6244 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0228 | 0.6244 | 1 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.011 | 0.1389 | 0.5 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0319 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0279 | 0.8331 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0279 | 0.8331 | 0.5 |
Treponema pallidum | polypeptide deformylase (def) | 0.0279 | 0.8331 | 0.5 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0091 | 0.0618 | 0.099 |
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.0319 | 1 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.1238 | 0.1983 |
Trypanosoma brucei | RNA helicase, putative | 0.0159 | 0.3387 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0106 | 0.1238 | 0.5 |
Chlamydia trachomatis | peptide deformylase | 0.0279 | 0.8331 | 0.5 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0181 | 0.4328 | 0.6931 |
Entamoeba histolytica | hypothetical protein | 0.0181 | 0.4328 | 0.6931 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.2938 | 0.35 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0106 | 0.1238 | 0.3655 |
Plasmodium falciparum | peptide deformylase | 0.0279 | 0.8331 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0279 | 0.8331 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0159 | 0.3387 | 0.3387 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0101 | 0.1022 | 0.1637 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0228 | 0.6244 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0279 | 0.8331 | 0.5 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0148 | 0.2938 | 0.4706 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0228 | 0.6244 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0221 | 0.5966 | 0.9555 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0106 | 0.1238 | 0.1983 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.1238 | 0.1983 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0273 | 0.8084 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0106 | 0.1238 | 0.1983 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0228 | 0.6244 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0106 | 0.1238 | 0.3655 |
Plasmodium vivax | peptide deformylase, putative | 0.0279 | 0.8331 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0157 | 0.3306 | 0.5294 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0157 | 0.3306 | 0.5294 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0228 | 0.6244 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 300 nM | Inhibition concentration against Escherichia coli peptide deformylase. | ChEMBL. | 12873500 |
IC50 (binding) | = 300 nM | Inhibition concentration against Escherichia coli peptide deformylase. | ChEMBL. | 12873500 |
MIC (functional) | > 200 uM | Antibacterial activity against Escherichia coli. | ChEMBL. | 12873500 |
MIC (functional) | > 200 uM | Antibacterial activity against Staphylococcus capitis. | ChEMBL. | 12873500 |
MIC (functional) | > 200 uM | Antibacterial activity against Escherichia coli. | ChEMBL. | 12873500 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.