Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Activation of Akt in human MCF7 cells expressing estrogen receptor at 10'-5 M after 4 hrs by Western blotting | ChEMBL. | 21208698 | |
Activity (functional) | Activation of Akt in human MCF7 cells expressing estrogen receptor at 10'-5 M after 9 hrs by Western blotting | ChEMBL. | 21208698 | |
Inhibition (functional) | = -53 % | Antiproliferative activity against human MCF7 cells expressing estrogen receptor assessed as cell growth inhibition 50 uM after 72 hrs by WST-1 assay relative to control | ChEMBL. | 21208698 |
Inhibition (functional) | = 52 % | Antiproliferative activity against human MCF7 cells expressing estrogen receptor at 10 uM after 72 hrs by WST-1 assay | ChEMBL. | 21208698 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.