Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.4285 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.4285 | 0.8312 |
Brugia malayi | Phospholipase A2 family protein | 0.0089 | 0.2843 | 0.2843 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.954 | 0.9949 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0089 | 0.2843 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.4285 | 0.8312 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0241 | 0.959 | 0.959 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2843 | 0.2964 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0241 | 0.959 | 0.959 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2843 | 0.2964 |
Schistosoma mansoni | thyroid hormone receptor | 0.0141 | 0.5155 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0241 | 0.959 | 1 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0089 | 0.2843 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0141 | 0.5155 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0141 | 0.5155 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.