Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0538 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0538 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0493 | 0 | 0.5 |
Schistosoma mansoni | d-amino acid oxidase | 0.0538 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Effective dose for 50 percent inhibition of gastric antisecretory activity in the 4 h pylorus-ligated rat; ND means no data | ChEMBL. | 6876082 |
ED50 (functional) | 0 mg kg-1 | Compound was evaluated for antiulcer activity in rats due to stress after oral administration; ND means no data | ChEMBL. | 6876082 |
Inhibition (functional) | = 22.9 % | Percent inhibition of gastric antisecretory activity in the 4 h pylorus-ligated rat to that of control at a dose of 100 mg/kg; not statistically significant | ChEMBL. | 6876082 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.