Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | telomerase reverse transcriptase, putative | 0.0096 | 0.264 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0096 | 0.264 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0096 | 0.264 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0096 | 0.264 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0096 | 0.264 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0256 | 0.7234 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0096 | 0.264 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0096 | 0.264 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0096 | 0.264 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Emax (functional) | = 27 % | Agonist activity at human 5HT2C receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization at 10 uM by FLIPR assay relative to control | ChEMBL. | 21195614 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.