Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0095 | 0.267 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0095 | 0.267 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0095 | 0.267 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0095 | 0.267 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0095 | 0.267 | 1 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0095 | 0.267 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0095 | 0.267 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0095 | 0.267 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0254 | 0.7245 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 30 uM | Activation of UTRN promoter in mouse H2K cells assessed as upregulation of UTRN production after 48 hrs by luciferase reporter linked assay | ChEMBL. | 21456623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.