Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | telomerase reverse transcriptase | 0.0097 | 0.264 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0097 | 0.264 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0097 | 0.264 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.0257 | 0.7234 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0097 | 0.264 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0097 | 0.264 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0097 | 0.264 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0097 | 0.264 | 1 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0097 | 0.264 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | < 0.1 uM | Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21489802 |
GI50 (functional) | = 0.14 uM | Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21489802 |
GI50 (functional) | = 0.15 uM | Growth inhibition of human ZR-75-1 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21489802 |
GI50 (functional) | = 0.18 uM | Growth inhibition of human KB cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21489802 |
GI50 (functional) | = 0.19 uM | Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21489802 |
GI50 (functional) | = 0.19 uM | Growth inhibition of human PC3 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21489802 |
GI50 (functional) | = 0.19 uM | Growth inhibition of human SiHa cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21489802 |
GI50 (functional) | = 2.1 uM | Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21489802 |
GI50 (functional) | = 2.7 uM | Growth inhibition of human COLO205 cells after 48 hrs by sulforhodamine B assay | ChEMBL. | 21489802 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.