Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | DNA polymerase I | 0.0225 | 0.0325 | 0.5 |
Schistosoma mansoni | DNA polymerase I | 0.0065 | 0 | 0.5 |
Chlamydia trachomatis | DNA polymerase I | 0.0225 | 0.0325 | 0.5 |
Toxoplasma gondii | 5'-3' exonuclease, N-terminal resolvase family domain-containing protein | 0.0078 | 0.0027 | 0.0102 |
Plasmodium falciparum | 5'-3' exonuclease, N-terminal resolvase-like domain, putative | 0.016 | 0.0193 | 0.0732 |
Trypanosoma cruzi | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.016 | 0.0193 | 0.0732 |
Mycobacterium ulcerans | DNA polymerase I | 0.0225 | 0.0325 | 1 |
Brugia malayi | Telomerase reverse transcriptase | 0.3623 | 0.7232 | 1 |
Trichomonas vaginalis | DNA polymerase I, putative | 0.0065 | 0 | 0.5 |
Plasmodium vivax | 5'-3' exonuclease, N-terminal resolvase-like domain, putative | 0.016 | 0.0193 | 0.0732 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.1362 | 0.2635 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1362 | 0.2635 | 1 |
Leishmania major | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.016 | 0.0193 | 0.0732 |
Trypanosoma cruzi | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.016 | 0.0193 | 0.0732 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.1362 | 0.2635 | 1 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.1362 | 0.2635 | 1 |
Mycobacterium leprae | PROBABLE DNA POLYMERASE I POLA | 0.0225 | 0.0325 | 0.5 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.1362 | 0.2635 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.1362 | 0.2635 | 0.5 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.1362 | 0.2635 | 1 |
Mycobacterium tuberculosis | Probable DNA polymerase I PolA | 0.0225 | 0.0325 | 1 |
Entamoeba histolytica | DNA-directed DNA polymerase, putative | 0.0065 | 0 | 0.5 |
Trypanosoma brucei | mitochondrial structure specific endonuclease I (SSE-1), putative | 0.016 | 0.0193 | 0.0732 |
Leishmania major | telomerase reverse transcriptase, putative | 0.1362 | 0.2635 | 1 |
Treponema pallidum | DNA polymerase I (polA) | 0.0225 | 0.0325 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | 0 uM | Inhibitory concentration of the compound was tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata ; ND denotes not determined | ChEMBL. | 12217358 |
Inhibition (binding) | = 53 % | Tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata | ChEMBL. | 12217358 |
Inhibition (binding) | = 53 % | Tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata | ChEMBL. | 12217358 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.