Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0158 | 0.0344 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0061 | 0.0061 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0158 | 0.0344 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0484 | 0.1986 | 0.1937 |
Loa Loa (eye worm) | hypothetical protein | 0.0484 | 0.1986 | 0.1986 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0484 | 0.1986 | 0.1489 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0101 | 0.0061 | 0.0061 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0773 | 0.3437 | 0.3437 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0484 | 0.1986 | 0.1489 |
Mycobacterium ulcerans | hypothetical protein | 0.0158 | 0.0344 | 0.5 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0158 | 0.0344 | 0.5 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0101 | 0.0061 | 0.0061 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0158 | 0.0344 | 0.5 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0773 | 0.3437 | 0.2681 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0484 | 0.1986 | 0.1937 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0773 | 0.3437 | 0.3437 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0773 | 0.3437 | 0.2681 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0484 | 0.1986 | 0.1489 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0773 | 0.3437 | 0.2681 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0158 | 0.0344 | 0.5 |
Loa Loa (eye worm) | calcium channel | 0.0484 | 0.1986 | 0.1986 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0205 | 0.0584 | 0.0526 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0484 | 0.1986 | 0.1489 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0484 | 0.1986 | 0.1489 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0484 | 0.1986 | 0.1937 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0484 | 0.1986 | 0.1489 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0484 | 0.1986 | 0.1937 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 63 % | Activation of UTRN promoter in mouse H2K cells assessed as upregulation of UTRN production at 10 uM after 48 hrs by luciferase reporter linked assay | ChEMBL. | 21456623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.